6-Nitrochrysene is a potent tumorigen in newborn mice.
6-Nitrochrysene is a potent tumorigen in newborn mice.
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6-Nitrochrysene 对新生小鼠来说是一种有效的致瘤原。
DOI：
10.1093/carcin/6.5.801
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发表时间：
1985
期刊：
影响因子：
4.7
通讯作者：
Wogan,GN
中科院分区：
文献类型：
--
作者：
BusbyJr,WF;Garner,RC;Chow,FL;Martin,CN;Stevens,EK;Newberne,PM;Wogan,GN
新生小鼠（BLU：Ha）肺腺瘤生物测定表明，6-硝基金霉素是一种高效的致瘤剂。在试验的最低剂量水平（总剂量：38.5 μg/小鼠）下，它诱导了100%的肺肿瘤发生率和150倍的数量增加（20.84个肿瘤/小鼠）。70%的6-硝基金霉素处理的小鼠患有恶性肺肿瘤（腺癌）。在给药组动物中也观察到肝脏淋巴瘤和结节性增生，但在对照组动物中未观察到。本文还讨论了6-硝基喹啉相对于其它多环芳烃及其单硝基衍生物的致瘤性。
A newborn mouse (BLU:Ha) lung adenoma bioassay demonstrated that 6-nitrochrysene was a highly potent tumorigen. It induced 100% incidence of lung tumors and a 150-fold increase in their number (20.84 tumors/mouse) at the lowest dose level tested (total dose: 38.5 μg/mouse). 70% of the 6-nitrochrysene treated mice had malignant lung tumors (adenocarcinomas). Lymphomas and nodular hyperplasia of the liver were also observed in treated, but not control, animals. The tumorigenicity of 6-nitrochrysene relative to other polynuclear aromatic hydrocarbons and their mononitro-derivatives has been discussed.