Human peripheral eosinophils have a specific mechanism to express gp91-phox, the large subunit of cytochrome b558.
Human peripheral eosinophils have a specific mechanism to express gp91-phox, the large subunit of cytochrome b558.
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人外周嗜酸性粒细胞具有表达 gp91-phox（细胞色素 b558 的大亚基）的特定机制。
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Yoshiro Tsuji
中科院分区：
文献类型：
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作者：
F. Kuribayashi;A. Kumatori;Shoichi Suzuki;Michio Nakamura;T. Matsumoto;Yoshiro Tsuji
嗜酸性粒细胞以及中性粒细胞、单核细胞和B淋巴细胞在X连锁慢性肉芽肿病患者中缺乏正常的细胞色素b558。嗜酸性粒细胞的X-连锁的男性患者，但是，充分表达表面细胞色素b558，产生超氧阴离子在正常范围内，明确表达大亚基的细胞色素b558（gp 91-phox）。他的单核白细胞含有减少量的gp 91-phox mRNA与正常的编码序列。所有编码序列和推测的poly（A）信号的gp 91-phox基因是正常的。这些结果表明，嗜酸性粒细胞表达gp 91-phox有一种特殊的机制，并建议该机制在于该基因的转录步骤。
Eosinophils as well as neutrophils, monocytes and B lymphocytes are noted for lacking normal cytochrome b558 in patients with X-linked chronic granulomatous disease. The eosinophils of an X-linked male patient, however, fully expressed surface cytochrome b558, generated superoxide anion to a normal extent and definitely expressed the large subunit of cytochrome b558 (gp91-phox). His mononuclear leukocytes contained a diminished amount of gp91-phox mRNA with normal coding sequences. All the coding sequences and a putative poly (A) signal of his gp91-phox gene were normal. These results indicate that eosinophils have a specific mechanism to express gp91-phox and suggest that the mechanism lies at the transcriptional step of the gene.