In Vitro Bioactivity of One- and Two-Dimensional Nanoparticle-Incorporated Bone Tissue Engineering Scaffolds.
In Vitro Bioactivity of One- and Two-Dimensional Nanoparticle-Incorporated Bone Tissue Engineering Scaffolds.
复制标题
DOI：
10.1089/ten.tea.2017.0117
复制
发表时间：
2017-08
影响因子：
--
通讯作者：
Jason T Rashkow;G. Lalwani;B. Sitharaman
中科院分区：
文献类型：
--
作者：
Jason T Rashkow;G. Lalwani;B. Sitharaman
本研究探讨了具有不同组成和形态的一维或二维纳米颗粒对生物可降解、生物相容性聚合物基质生物活性的影响。0.2重量%的多壁碳纳米管、多壁石墨烯纳米带、氧化石墨烯纳米片（GONP）、二硫化钼纳米片（MSNP）或二硫化钨纳米管（WSNTs）均匀地分散在聚（乳酸-共-乙醇酸）（PLGA）聚合物中。然后将PLGA或掺入纳米颗粒的PLGA与模拟体液（SBF）在生理条件下孵育1、3、7或14天。评估了对照和掺入的支架上的磷灰石收集。在SBF培养1天后，所有组的表面上均显示出磷灰石沉淀。SBF孵育14天后，与PLGA支架相比，掺入GONPs、MSNPs或WSNTs的支架显示出显著更高的磷酸盐积累。与GONPs，MSNPs或WSNTs结合的支架应在体内进行研究，以进一步研究潜在的生物活性，从而增强骨-植入物界面的整合和组织修复。
This study investigates the effect of incorporation of one- or two-dimensional nanoparticles with distinct composition and morphology on the bioactivity of biodegradable, biocompatible polymer matrices. 0.2 wt% multiwalled carbon nanotubes, multiwalled graphene nanoribbons, graphene oxide nanoplatelets (GONPs), molybdenum disulfide nanoplatelets (MSNPs), or tungsten disulfide nanotubes (WSNTs) were uniformly dispersed in poly(lactic-co-glycolic acid) (PLGA) polymer. PLGA or nanoparticle-incorporated PLGA were then incubated with simulated body fluid (SBF) under physiological conditions for 1, 3, 7, or 14 days. Apatite collection on control and incorporated scaffolds was assessed. All groups showed apatite precipitate on the surface after 1 day of SBF incubation. After 14 days of SBF incubation, scaffolds incorporated with GONPs, MSNPs, or WSNTs showed significantly higher phosphate accumulation compared to PLGA scaffolds. Scaffolds incorporated with GONPs, MSNPs, or WSNTs should be studied in vivo to further investigate potential bioactivity, leading to enhanced integration and tissue repair at the bone-implant interface.