The iron metallome in eukaryotic organisms.
The iron metallome in eukaryotic organisms.
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DOI：
10.1007/978-94-007-5561-1_8
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Outten, Caryn E
中科院分区：
文献类型：
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作者：
Dlouhy, Adrienne C;Outten, Caryn E
这一章的重点是铁金属组在真核生物在细胞和亚细胞水平，包括属性，利用金属蛋白，运输，储存和调节这些过程。在模型真核生物酿酒酵母和哺乳动物细胞的研究将突出。铁特性的讨论将集中在细胞内铁的形态和定位以及应对低铁生物利用度和铁毒性的细胞和分子机制。铁金属蛋白部分将强调血红素、铁硫簇和非血红素铁中心，特别是它们的细胞作用和组装机制。关于铁的吸收，运输和储存的部分将比较酵母和哺乳动物细胞输入铁的方法，这种铁如何被带入各种细胞器，以及铁储存蛋白的类型。这些过程的调节将在转录、转录后和翻译后水平上在酵母和哺乳动物细胞之间进行比较。
This chapter is focused on the iron metallome in eukaryotes at the cellular and subcellular level, including properties, utilization in metalloproteins, trafficking, storage, and regulation of these processes. Studies in the model eukaryote Saccharomyces cerevisiae and mammalian cells will be highlighted. The discussion of iron properties will center on the speciation and localization of intracellular iron as well as the cellular and molecular mechanisms for coping with both low iron bioavailability and iron toxicity. The section on iron metalloproteins will emphasize heme, iron-sulfur cluster, and non-heme iron centers, particularly their cellular roles and mechanisms of assembly. The section on iron uptake, trafficking, and storage will compare methods used by yeast and mammalian cells to import iron, how this iron is brought into various organelles, and types of iron storage proteins. Regulation of these processes will be compared between yeast and mammalian cells at the transcriptional, post-transcriptional, and post-translational levels.