Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death.
Cardiac Innervation and the Autonomic Nervous System in Sudden Cardiac Death.
复制标题
心脏神经神经和心脏猝死的自主神经系统。
DOI：
10.1016/j.ccep.2017.08.002
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发表时间：
2017-12
影响因子：
--
通讯作者：
Vaseghi M
中科院分区：
文献类型：
--
作者：
Huang WA;Boyle NG;Vaseghi M
自主神经系统的神经重构与心源性猝死有重要关系。心脏兴奋性和增殖结构受自主神经支配。心脏病通过引起心肌、内在心脏神经节、心外胸内交感神经节、胸外神经节、脊髓、脑干以及高级中枢和皮层等水平的神经重塑而易发生恶性室性心律失常。这些水平的治疗策略旨在恢复交感神经和副交感神经分支之间的平衡。了解这种复杂的神经网络将为心脏性猝死的治疗提供进一步重要的治疗见解。
Neural remodeling in the autonomic nervous system contributes significantly to sudden cardiac death. The fabric of cardiac excitability and propagation are controlled by autonomic innervation. Heart disease predisposes to malignant ventricular arrhythmias by causing neural remodeling at the level of the myocardium, the intrinsic cardiac ganglia, extra-cardiac intrathoracic sympathetic ganglia, extra-thoracic ganglia, spinal cord, and the brainstem, as well as the higher centers and the cortex. Therapeutic strategies at each of these levels aim to restore the balance between the sympathetic and parasympathetic branches. Understanding this complex neural network will provide further important therapeutic insights into the treatment of sudden cardiac death.