An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice
An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice
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DOI：
10.1016/j.bbrc.2020.12.112
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发表时间：
2021-01-16
影响因子：
3.1
通讯作者：
Sugimoto, Masataka
中科院分区：
文献类型：
--
作者：
Kawaguchi, Koichiro;Hashimoto, Michihiro;Sugimoto, Masataka
氧化应激是哺乳动物细胞衰老的主要原因之一。氧代谢产生的过量活性氧是致病的，并促进组织老化。肺组织比其他器官更容易受到氧化应激的影响，因为它直接暴露于环境应激。肺组织的老化会增加慢性疾病的风险。衰老细胞在衰老过程中在组织中积累，并导致与衰老相关的发病率;然而，细胞衰老在肺衰老和疾病中的作用尚未被详细阐明。为了阐明氧化应激诱导的细胞衰老在与衰老相关的肺功能下降中的生理作用，本文研究了抗氧化剂N-乙酰-L-半胱氨酸（NAC）对小鼠肺细胞衰老和老化的影响。1岁小鼠给予NAC可降低肺组织中衰老相关基因的表达。给予NAC的小鼠肺功能和肺形态部分恢复。总的来说，这些结果表明，氧化应激是体内细胞衰老的主要诱导物，并且氧化应激的控制可以防止肺衰老和疾病。(C)2021爱思唯尔公司All rights reserved.
Oxidative stress is one of the major causes of cellular senescence in mammalian cells. The excess amount of reactive oxygen species generated by oxygen metabolism is pathogenic and facilitates tissue aging. Lung tissue is more susceptible to oxidative stress than other organs because it is directly exposed to environmental stresses. The aging of lung tissues increases the risk of chronic diseases. Senescent cells accumulate in tissues during aging and contribute to aging-associated morbidity; however, the roles of cellular senescence in lung aging and diseases have not yet been elucidated in detail.To clarify the physiological role of oxidative stress-induced cellular senescence in aging-associated declines in pulmonary function, we herein investigated the effects of the antioxidant N-acetyl-Lcysteine (NAC) on lung cellular senescence and aging in mice. The administration of NAC to 1-year-old mice reduced the expression of senescence-associated genes in lung tissue. Pulmonary function and lung morphology were partly restored in mice administered NAC. Collectively, these results suggest that oxidative stress is a major inducer of cellular senescence in vivo and that the control of oxidative stress may prevent lung aging and diseases. (C) 2021 Elsevier Inc. All rights reserved.