The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia
The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia
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DOI：
10.1002/ajh.23397
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发表时间：
2013-04-01
影响因子：
12.8
通讯作者：
Earley, Christopher J.
中科院分区：
文献类型：
--
作者：
Allen, Richard P.;Auerbach, Sarah;Earley, Christopher J.
不宁腿综合征（RLS）是一种常见的、未被认识到的疾病，它会扰乱睡眠，降低生活质量。尽管低外周铁和RLS的患病率和严重程度增加之间存在明确的关系，但缺铁性贫血（IDA）人群中RLS的患病率和临床意义尚不清楚。在本研究中，所有在1年期间（2011年3月至2012年3月）因贫血转诊至社区血液学实践的新发患者，如果患有IDA且未接受RLS治疗，则均纳入研究。患者完成了一份确认RLS的有效问卷、血液检查和睡眠活力问卷（SVQ）。比较RLS患者与无RLS患者在SVQ、血液检查、基线特征和睡眠质量方面的差异。对343例患者进行了评价，251例（89.2%为女性，平均年龄45.6岁）纳入研究。有临床意义的RLS（RLS患者）的患病率为23.9%，是普通人群的9倍。IDA-RLS患者报告睡眠质量较差，睡眠时间减少，疲劳增加，与IDA无RLS患者相比，白天能量减少。血液检查与RLS诊断无关，但非洲裔美国人比白人患者更不可能发生RLS。临床上显著的RLS通常与IDA一起发生，与单独的IDA相比，IDA产生更大的睡眠中断和更短的睡眠时间。这表明需要鉴定患有IDA的RLS，并考虑对这一相当大的亚组进行适当的治疗干预：积极的铁治疗以减少RLS症状或RLS药物治疗或两者兼而有之。Am. J. Hematol. 88：261264，2013. (c)2013 Wiley Periodicals，Inc.
Restless Legs Syndrome (RLS) a common, under-recognized disorder disrupts sleep and diminishes quality of life. Despite a clear relation between low peripheral iron and increased prevalence and severity of RLS, the prevalence and clinical significance of RLS in iron-deficient anemic (IDA) populations is unknown. In this study all new patients referred for anemia to a community-based hematology practice over a 1-year period (March 20112012) were included if they had IDA and no RLS treatment. Patients completed a validated questionnaire identifying RLS, blood tests, and a sleep-vitality questionnaire (SVQ). Patients with RLS were compared to patients with no RLS for differences on SVQ, blood tests, baseline characteristics, and sleep quality. Three hundred forty-three patients were evaluated and 251 (89.2% female, average age of 45.6 years) included in the study. The prevalence of clinically significant RLS (RLS sufferers) was 23.9%, nine times higher than the general population. IDA-RLS sufferers reported poorer quality of sleep, decreased sleep time, increased tiredness, and decreased energy during the day compared to patients with IDA without RLS. Blood tests did not relate to RLS diagnosis but RLS was less likely for African-American than Caucasian patients. Clinically significant RLS occurs commonly with IDA producing much greater disruption of sleep and shorter sleep times than does IDA alone. This indicates the need for identification of RLS with IDA and consideration of appropriate therapeutic interventions for this sizeable subgroup: either aggressive iron treatment to reduce the RLS symptoms or medications for RLS or both. Am. J. Hematol. 88:261264, 2013. (c) 2013 Wiley Periodicals, Inc.