Antifungal Amphiphilic Aminoglycosides.
Antifungal Amphiphilic Aminoglycosides.
复制标题
DOI：
10.1039/c4md00078a
复制
发表时间：
2014-08-01
期刊：
影响因子：
--
通讯作者：
Takemoto JY
中科院分区：
文献类型：
--
作者：
Chang CW;Takemoto JY
烷基和其他疏水基团与传统的抗菌卡那霉素和新霉素的连接产生具有改变的抗微生物性质的两亲性氨基糖苷。在这篇综述中，我们总结了发现的两亲性卡那霉素是抗真菌，但不是抗菌，并抑制真菌的生长，通过扰动质膜功能。由于对植物和哺乳动物细胞的毒性较低，它们似乎特异性靶向真菌质膜。这些新的抗真菌药物为对抗真菌病原体提供了新的选择，并且是恢复旧药物以应对新的治疗挑战的例子。
The attachment of alkyl and other hydrophobic groups to traditional antibacterial kanamycins and neomycins creates amphiphilic aminoglycosides with altered antimicrobial properties. In this review, we summarize the discovery of amphiphilic kanamycins that are antifungal, but not antibacterial, and that inhibit the growth of fungi by perturbation of plasma membrane functions. With low toxicities against plant and mammalian cells, they appear to specifically target the fungal plasma membrane. These new antifungal agents offer new options for fighting fungal pathogens and are examples of reviving old drugs to confront new therapeutic challenges.