Hedgehog signaling pathway in neuroblastoma differentiation
Hedgehog signaling pathway in neuroblastoma differentiation
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DOI：
10.1016/j.jpedsurg.2010.08.020
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发表时间：
2010-12-01
影响因子：
2.4
通讯作者：
Taguchi, Tomoaki
中科院分区：
文献类型：
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作者：
Souzaki, Ryota;Tajiri, Tatsuro;Taguchi, Tomoaki
目的：Hedgehog（Hh）信号通路在某些成人癌症中被激活。另一方面，Hh信号通路在胚胎神经嵴的发育中起着重要作用。本研究的目的是显示Hh信号通路在神经母细胞瘤（NB），一种起源于神经嵴细胞的儿科恶性肿瘤中的激活，并揭示Hh信号通路在NB发展中的意义。研究方法：本研究采用免疫组织化学方法分析了82例NB和10例节细胞神经母细胞瘤中Hh信号通路反式激活因子Sonic hedgehog（Shh）、GLI 1和Patched 1（Ptch 1）的表达。对所有92例病例进行MYCN扩增状态评价。结果：92例中Shh阳性67例（73%），GLI 1阳性62例（67%），Ptch 1阳性73例（79%）。在20例MYCN扩增的病例中，Shh和GLI 1仅2例（10%）阳性，Ptch 1 4例（20%）阳性（MYCN扩增vs无MYCN扩增，P
Purpose: The hedgehog (Hh) signaling pathway is activated in some adult cancers. On the other hand, the Hh signaling pathway plays an important role in the development of the neural crest in embryos. The aim of this study is to show the activation of Hh signaling pathway in neuroblastoma (NB), a pediatric malignancy arising from neural crest cells, and to reveal the meaning of the Hh signaling pathway in NB development. Methods: This study analyzed the expression of Sonic hedgehog (Shh), GLI1, and Patched 1 (Ptch1), transactivators of Hh signaling pathway, by immunohistochemistry in 82 NB and 10 gang-lioneuroblastoma cases. All 92 cases were evaluated for the status of MYCN amplification. Results: Of the 92 cases, 67 (73%) were positive for Shh, 62 cases (67%) were positive for GLI1, and 73 cases (79%) were positive for Ptch1. Only 2 (10%) of the 20 cases with MYCN amplification were positive for Shh and GLI1, and 4 cases (20%) were positive for Ptch1 (MYCN amplification vs no MYCN amplification, P