Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas.
Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas.
复制标题
CD44 在导管细胞癌和胰腺导管内肿瘤中的表达。
作者：
K. Satoh;T. Shimosegawa;M. Koizumi;T. Toyota
选择性剪接的CD44亚型的表达，特别是所谓的变异型外显子v5和v6的表达与许多人类癌症的进展有关。用外显子特异性单抗对28例人胰腺肿瘤(16例浸润性导管细胞腺癌和12例导管内肿瘤)的标准CD44和带有外显子v5和v6的CD44变异体的表达进行了检测。CD44在浸润性导管细胞癌和导管内肿瘤中均有表达。CD44变异体(v5和v6)也在几乎所有的导管细胞癌中表达。相反，导管内肿瘤中CD44-v5和-v6的表达很少，尤其是v6外显子。CD44-v5和v6的表达是浸润性癌的共同特征，而在导管内肿瘤中表达不明显。这些发现可能与导管细胞癌的侵袭性和/或胰腺导管内肿瘤的良性生物学行为有关。
The expression of alternatively spliced CD44 isoforms, especially so-called variant exons v5 and v6, has been shown to correlate with the progression of a number of human cancers examined the expression of standard CD44 and CD44 variants with exons v5 and v6 in 28 cases of human pancreatic tumors (16 cases of invasive duct cell adenocarcinoma and 12 cases of intraductal neoplasms) by immunohistochemistry using exon specific monoclonal antibodies. The expression of standard CD44 was frequently observed in both invasive duct cell carcinomas and intraductal neoplasms. The expression of CD44 variants (v5 and v6) was also seen in almost all duct cell carcinomas. In contrast, intraductal neoplasms infrequently expressed CD44-v5 and -v6, particularly v6 exon. Expression of CD44-v5 and v6 was a common characteristic of invasive cancer, while it was not so prominent in intraductal neoplasm. These findings may be related to the invasiveness of duct cell carcinoma and/or the benign biological behavior of intraductal neoplasm of the pancreas.