PULMONARY ACINUS - GEOMETRY AND MORPHOMETRY OF THE PERIPHERAL AIRWAY SYSTEM IN RAT AND RABBIT
PULMONARY ACINUS - GEOMETRY AND MORPHOMETRY OF THE PERIPHERAL AIRWAY SYSTEM IN RAT AND RABBIT
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DOI：
10.1002/aja.1001800204
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发表时间：
1987-10-01
影响因子：
--
通讯作者：
WEIBEL, ER
中科院分区：
文献类型：
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作者：
RODRIGUEZ, M;BUR, S;WEIBEL, ER
利用硅橡胶模型研究了大鼠和兔肺腺泡内气道的几何形状和形态测量。腺泡被定义为“末端”细支气管远端的肺泡气道复合体，被从支气管树上切除。在这两个物种中，腺泡体积在一个数量级的大小范围内遵循对数正态分布。当充气水平为总肺容量的 60% 时，大鼠的平均体积为 1.86 mm3，兔子的平均体积为 3.46 mm3。在不同体积的腺泡的代表性样本上，分支模式被表征为不规则二分法，并测量了节段长度和内径和外径。大鼠的腺泡平均有六代，兔子的平均腺泡有七代。每一代都显示出节段长度和内径的减小。发现平均纵向路径长度.sbd.，即从初始腺泡段到末端囊.sbd.的距离，取决于两个物种中腺泡体积的立方根。经计算，大鼠和兔子的厚度分别为 1.46 和 1.95 毫米。
The geometry and morphometry of intraacinar airways in rat and rabbit lungs were studied from silicone rubber casts. Acini, defined as the complex of alveolated airways distal to the "terminal" bronchiole, were trimmed off the bronchial tree. In both species, the acinar volume followed a log-normal distribution over a range in size of one order of magnitude. At an inflation level of 60% total lung capacity, their mean volume was 1.86 mm3 in the rat and 3.46 mm3 in the rabbit. On a representative sample of acini of different volumes, the branching pattern was characterized as irregular dichotomy, and the segment length and inner and outer diameters were measured. The average acinus had a mean of six generations in the rat and seven in the rabbit. Both showed a decrease in segment length and inner diameter with each generation. The mean longitudinal pathway length.sbd.that is, the distance from the initial acinar segment to the terminal sacs.sbd.was found to depend on the cube root of the acinar volume in both species. It was calculated at 1.46 and 1.95 mm for rat and rabbit, respectively.