Stem cell regulation by polycomb repressors: postponing commitment
Stem cell regulation by polycomb repressors: postponing commitment
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DOI：
10.1016/j.ceb.2008.01.004
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发表时间：
2008-04-01
影响因子：
7.5
通讯作者：
van Lohuizen, Maarten
中科院分区：
文献类型：
--
作者：
Pietersen, Alexandra M.;van Lohuizen, Maarten
多梳族蛋白（Polycomb group proteins，PcGs）通过染色质修饰参与基因抑制，是维持胚胎干细胞和成体干细胞所必需的。全基因组研究表明，PcG靶向的基因主要是发育转录因子。在胚胎干细胞中，这些基因不仅携带抑制性PcG标记，而且还携带激活标记，导致所谓的“二价结构域”。新的数据表明，具有二价结构域的基因在分化时被引发差异表达。我们提出，二价结构域分解为活性状态或抑制状态构成了细胞命运决定，并且通过推迟这些决定，PcG有助于多能性。
Polycomb group proteins (PcGs) are involved in gene repression through chromatin modifications and required for the maintenance of both embryonic and adult stem cells. Genome-wide studies demonstrate that genes targeted by PcG are predominantly developmental transcription factors. In embryonic stem cells, these genes carry not only a repressive PcG mark but also an activating mark, resulting in so-called 'bivalent domains'. New data suggest that genes with bivalent domains are primed for differential expression upon differentiation. We propose that the resolution of a bivalent domain into either an active or repressed state constitutes a cell fate decision, and that by postponing these decisions PcG contributes to pluripotency.