Modulation of acute and chronic inflammation of the lung by GITR and its ligand
Modulation of acute and chronic inflammation of the lung by GITR and its ligand
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DOI：
10.1196/annals.1381.040
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Riccardi, Carlo
中科院分区：
文献类型：
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作者：
Nocentini, Giuseppe;Cuzzocrea, Salvatope;Riccardi, Carlo
糖皮质激素诱导的TNFR相关（GITR）蛋白是肿瘤坏死因子受体超家族的成员，在先天性和适应性免疫系统的许多组分中表达，并在与其配体（GITRL）相互作用后调节其活化。在这里，我们回顾和讨论在以前的出版物中描述的结果，其中使用两个实验系统评估GITR/GITRL系统在肺部炎症中的作用。我们还讨论了GITR/GITRL系统所起的促炎作用以及GITR融合蛋白在抑制炎症中的潜在用途。
Glucocorticoid-induced TNFR-related (GITR) protein, a member of the tumor necrosis factor receptor superfamily, is expressed in many components of the innate and adaptive immune system and modulates their activation following interaction with its ligand (GITRL). Here we review and discuss results described in previous publications where the role of the GITR/GITRL system in lung inflammation was evaluated using two experimental systems. We also discuss the proinflammatory role played by the GITR/GITRL system and the potential use of GITR fusion protein in inhibiting inflammation.