Fatigue in rheumatoid arthritis and its relation to interleukin-6 serum level
Fatigue in rheumatoid arthritis and its relation to interleukin-6 serum level
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DOI：
10.1016/j.ejr.2012.08.004
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发表时间：
2012-10-01
影响因子：
0.9
通讯作者：
Moneim, Riham Abdel
中科院分区：
文献类型：
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作者：
Helal, Abdel Moneim H.;Shahine, Enas M.;Moneim, Riham Abdel
患者和方法：本研究包括30例根据2010年ACR-EULAR RA分类标准诊断的RA患者和15例健康对照。纳入的患者年龄在18岁以上，符合2010年ACR-EULAR分类标准>= 6 / 10分。采用28关节疾病活动性评分（DAS28）、红细胞沉降率（ESR）、c反应蛋白（CRP）评估疾病活动性。采用布里斯托尔类风湿性关节炎疲劳多维问卷（BRAF-MDQ）评估疲劳程度，并测量患者和对照组的血清IL-6水平。结果：患者BRAF-MDQ（平均50.6 +/- 15.2）明显高于对照组（平均7.8 +/- 3.7）（p< 0.001）。对照组患者血清IL-6水平分别为35.05 +/- 21.23 pg/ml和4.72 +/- 3.09 pg/ml （p< 0.001）。DAS 28在4.33 ~ 7.67之间，平均1小时ESR为43.57 mm， 76.7%的患者CRP呈阳性。RA患者BRAF-MDQ评分与血清IL-6水平（r = 0.947, p < 0.001）、ESR （r = 0.509, p < 0.001）、CRP阳性（r = 0.411, p= 0.005）呈显著相关。血清IL-6水平与患者ESR （r = 0.463, p < 0.001）、CRP （r = 0.376, p= 0.01）相关。结论：疲劳是RA患者常见的症状，其评分高于健康对照组，应在所有RA患者中采用与不同文化相匹配的简单疲劳问卷进行测量。随着血清IL-6水平的升高，疲劳变得更加突出，这与疾病的持续时间和活动无关。(C) 2012年埃及关节疾病和关节炎学会。制作和托管由爱思唯尔B.V.根据CC by - nc - nd许可开放获取。
Patients and methods: The study included 30 patients with RA diagnosed according to the 2010 ACR-EULAR classification criteria for RA and 15 healthy controls. Patients were included if they were above 18 years and fulfilled a score >= 6 over 10 of the 2010 ACR-EULAR classification criteria for RA. Disease activity was assessed using 28 joint disease activity score (DAS28), erythrocytes sedimentation rate (ESR), C-reactive protein (CRP). Fatigue was assessed with the Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire (BRAF-MDQ) and serum IL-6 level was measured in patients and controls.Results: The BRAF-MDQ was significantly higher among patients (mean = 50.6 +/- 15.2) than controls (mean= 7.8 +/- 3.7) (p< 0.001). Patients' mean IL-6 serum level was 35.05 +/- 21.23 pg/ml and 4.72 +/- 3.09 pg/ml among control subjects (p< 0.001). DAS 28 ranged between 4.33 and 7.67, mean 1st hour ESR was 43.57 mm and CRP was positive in 76.7% of patients. Significant correlations were found between BRAF-MDQ score and serum IL-6 level (r = 0.947, p < 0.001), ESR (r = 0.509, p < 0.001) as well as CRP positivity (r = 0.411, p= 0.005) in RA patients. Serum IL-6 level correlated with ESR (r = 0.463, p < 0.001) and CRP (r = 0.376, p= 0.01) among patients.Conclusion: Fatigue is a common symptom and scores higher among RA patients than healthy controls and should be measured in all RA patients with simple fatigue questionnaires matching with different cultures. Fatigue becomes more prominent as serum IL-6 level increases independently of the disease duration and activity. (C) 2012 Egyptian Society for Joint Diseases and Arthritis. Production and hosting by Elsevier B.V. Open access under CC BY-NC-ND license.