The BILAG-2004 index is sensitive to change for assessment of SLE disease activity.
The BILAG-2004 index is sensitive to change for assessment of SLE disease activity.
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DOI：
10.1093/rheumatology/kep064
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Gordon C
中科院分区：
文献类型：
--
作者：
Yee CS;Farewell V;Isenberg DA;Griffiths B;Teh LS;Bruce IN;Ahmad Y;Rahman A;Prabu A;Akil M;McHugh N;Edwards C;D'Cruz D;Khamashta MA;Maddison P;Gordon C
Objective.确定BILAG-2004指数是否对SLE疾病活动性评估的变化敏感。方法.这是一项针对SLE患者的前瞻性多中心纵向研究。在每次评估时，收集疾病活动性（BILAG-2004指数）和治疗数据。使用总体BILAG-2004指数评分（由任何单个系统获得的最高评分确定）和所有系统评分进行分析。通过确定两次连续访视之间疾病活动性变化与治疗变化之间的关系，评估对变化的敏感性。使用多项逻辑回归进行统计分析。结果来自347例SLE患者的1761项评估提供了1414项观察结果用于分析。22.7%的观察结果显示两次访视之间的治疗增加，37.3%的观察结果显示治疗减少，40.0%的观察结果显示治疗不变。总体BILAG-2004指数评分的增加与治疗增加相关，与治疗减少呈负相关。总体BILAG-2004指数评分降低与治疗减少相关，与治疗增加呈负相关。总体BILAG-2004指数评分的变化与治疗变化有差异性相关，评分变化越大，预测能力越强。大多数系统评分的增加与治疗增加独立相关，任何系统评分的降低与治疗增加之间均无显著相关性。结论. BILAG-2004指数对变化敏感，适用于SLE的纵向研究。
Objective. To determine if the BILAG-2004 index is sensitive to change for assessment of SLE disease activity. Methods. This was a prospective multi-centre longitudinal study of SLE patients. At every assessment, data were collected on disease activity (BILAG-2004 index) and treatment. Analyses were performed using overall BILAG-2004 index score (as determined by the highest score achieved by any of the individual systems) and all the systems scores. Sensitivity to change was assessed by determining the relationship between change in disease activity and change in therapy between two consecutive visits. Statistical analyses were performed using multinomial logistic regression. Results. There were 1761 assessments from 347 SLE patients that contributed 1414 observations for analysis. An increase in therapy between visits occurred in 22.7% observations, while 37.3% had a decrease in therapy and in 40.0% therapy was unchanged. Increase in overall BILAG-2004 index score was associated with increase in therapy and inversely associated with decrease in therapy. Decrease in overall BILAG-2004 index score was associated with decrease in therapy and was inversely associated with increase in therapy. Changes in overall BILAG-2004 index score were differentially related to change in therapy, with greater change in score having greater predictive power. Increase in the scores of most systems was independently associated with an increase in treatment and there was no significant association between decreases in the score of any system with an increase in therapy. Conclusions. The BILAG-2004 index is sensitive to change and is suitable for use in longitudinal studies of SLE.
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影响因子：
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作者：
Petri, Michelle;Kasitanon, Nuntana;Zoma, Asad
通讯作者：
Zoma, Asad
影响因子：
7.2
作者：
Chang, E;Abrahamowicz, M;Fortin, PR
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Fortin, PR
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作者：
Williams, RL
通讯作者：
Williams, RL
影响因子：
5.5
作者：
Isenberg, DA;Rahman, A;Gordon, C
通讯作者：
Gordon, C
影响因子：
--
作者：
LIANG, MH;SOCHER, SA;SCHUR, PH
通讯作者：
SCHUR, PH