Increase of beta-endorphin concentrations in the plasma and pituitary neuro-intermediate lobe of the rat on the afternoon of proestrus.
Increase of beta-endorphin concentrations in the plasma and pituitary neuro-intermediate lobe of the rat on the afternoon of proestrus.
复制标题
发情前期下午大鼠血浆和垂体神经中间叶中β-内啡肽浓度增加。
DOI：
10.1016/0024-3205(82)90103-5
复制
发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
Yen,SS
中科院分区：
文献类型：
--
作者：
Ishizuka,B;Wilkes,MM;Stewart,RD;Rasmussen,DD;Yen,SS
在发情前期和发情间期第 1 天的 1000、1400 和 1900 小时，通过放射免疫分析 (RIA) 和凝胶过滤色谱法对雌性大鼠血浆以及垂体前叶和神经中间叶（AP 和 NIL）中的 β-内啡肽 (β-EP) 浓度进行定量。发情间期第 1 天，血浆、AP 或 NIL 中的 β-EP 没有显着变化。发情前期，血浆中的 β-EP 和 NIL（而非 AP）从 1000 小时到 1400 小时显着增加，并在 1900 小时恢复到基础水平。 NIL和血浆中β-EP增加的时间过程与发情前期下午催乳素和促性腺激素激增的时间顺序一致，表明NIL中的β-EP可能参与这些神经内分泌事件的调节。
β-endorphin (β-EP) concentrations in the plasma and the anterior and neuro-intermediate lobes of the pituitary (AP and NIL) were quantitated by radioimmunoassay (RIA) and gel filtration chromatography in female rats at 1000, 1400, and 1900 h on the day of proestrus and diestrus day-1. There were no significant changes in β-EP in the plasma, AP, or NIL on diestrus day-1. On proestrus, β-EP in the plasma and NIL, but not the AP, increased significantly from 1000 to 1400 h and returned to basal levels by 1900 h. The time course of this increase of β-EP in the NIL and plasma is consistent with the temporal sequence of the prolactin and gonadotropin surges on the afternoon of proestrus, suggesting that β-EP in the NIL may be involved in the regulation of these neuroendocrine events.