Genetics of aging
Genetics of aging
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DOI：
10.1126/science.278.5337.407
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发表时间：
1997-10-17
期刊：
影响因子：
56.9
通讯作者：
Tanzi, RE
中科院分区：
文献类型：
--
作者：
Finch, CE;Tanzi, RE
遗传在决定寿命方面的作用是复杂而矛盾的，尽管寿命的遗传能力相对较小，但一些遗传变异显著地改变了哺乳动物和无脊椎动物的衰老，对与年龄相关的疾病和寿命既有积极的影响，也有消极的影响。在某些例子中，基因变异改变了代谢途径，从而可能介导与影响寿命的营养和其他环境因素的相互作用。考虑到影响老年生存和健康的遗传风险因素的影响相对较小且外显率不同，生活方式和其他环境影响可能会深刻地改变衰老的结果。
The role of genetics in determining life-span is complex and paradoxical, Although the heritability of life-span is relatively minor, some genetic variants significantly modify senescence of mammals and invertebrates, with both positive and negative impacts on age-related disorders and life-spans, In certain examples, the gene variants alter metabolic pathways, which could thereby mediate interactions with nutritional and other environmental factors that influence life-span, Given the relatively minor effect and variable penetrance of genetic risk factors that appear to affect survival and health at advanced ages, life-style and other environmental influences may profoundly modify outcomes of aging.