Isoporous membranes with sub-10 nm pores prepared from supramolecular interaction facilitated block copolymer assembly and application for protein separation
Isoporous membranes with sub-10 nm pores prepared from supramolecular interaction facilitated block copolymer assembly and application for protein separation
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DOI：
10.1016/j.memsci.2018.08.033
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发表时间：
2018-11
影响因子：
9.5
通讯作者：
Guo-dong Zhu;Yu-rong Ying;Xuan Li;Yang Liu;Cao Yang;Zhuan Yi;Cong-jie Gao
中科院分区：
文献类型：
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作者：
Guo-dong Zhu;Yu-rong Ying;Xuan Li;Yang Liu;Cao Yang;Zhuan Yi;Cong-jie Gao
孔径小于10 nm的等孔膜对分子分离具有重要意义。然而，采用包含自组装和非溶剂诱导相分离(SNIP)的工艺来制备这类膜是一项具有挑战性的工作，到目前为止只有很少的工作进行。在这里，我们描述了用特殊设计的添加剂从定义良好的剪切剂中制备出孔径可达8.6 nm、孔密度可达1.3 × 1015/m2的膜，该添加剂选择性地与聚(4-乙烯基吡啶)相互作用，并促进了聚苯乙烯-嵌段-聚(4-乙烯基吡啶)(S4VP)的相分离。用核磁共振研究了添加剂与S4VP在铸膜液中的相互作用，并用小角X射线散射(SAXS)分析了相分离增强的原因。系统地考察了添加剂与P4VP的配比、溶剂组成、聚合物浓度等制备条件对膜形成的影响。用扫描电子显微镜(SEM)对膜的形貌和孔径进行了分析，最终确定了它们对不同大小和电荷的蛋白质的截留率。我们的方法为制备分子分离所需的孔径小于10 nm的等孔膜开辟了一条途径。
Isoporous membranes with pore size smaller than 10 nm are significantly important for molecular separation. However, preparation of such membranes from process containing self-assembly and non-solvent induced phase separation (SNIPS) is challenging, and only few works were conducted until now. Herein, we described that membranes with pore size down to 8.6 nm and pore density up to 1.3 × 1015/m2were generated from the well-defined SNIPS with the specially designed additive, which interacted selectively with poly(4-vinylpyridine) and facilitated the phase separation when membranes were prepared from the polystyrene-block-poly (4-vinylpyridine) (S4VP). Interaction of the additive with S4VP in casting solutions was probed by nuclear magnetic resonance (NMR), which was ascribed to the reason for the enhanced phase separation that was inspected by small angle X-ray scattering (SAXS). The effect of preparation conditions, such as the ratios of the additive to P4VP, the compositions of solvent, and the polymer concentrations on membrane formation were systematically investigated. The morphologies and pore size on membranes were analyzed by scanning electron microscope (SEM), and their rejections to proteins of varied size and charges were finally determined. Our method showed herein has opened an access to the preparation of isoporous membranes with sub-10 nm pores that were desirable for molecular separation.