Priming cancer cells for drug resistance: role of the fibroblast niche.
Priming cancer cells for drug resistance: role of the fibroblast niche.
复制标题
DOI：
10.1007/s11515-014-1300-8
复制
发表时间：
2014-02-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
常规和靶向化疗仍然是治疗实体瘤的整体策略。尽管有大量的抗癌药物可用，但化疗并不能完全根除疾病。疾病复发和耐药肿瘤的生长仍然是抗癌治疗中的重要问题。为了开发更有效的治疗策略，重要的是要了解耐药性的潜在细胞和分子机制。人们普遍认为，癌细胞并不单独发挥作用，而是通过与周围肿瘤微环境的相互作用而进化。作为肿瘤微环境的关键细胞组分，成纤维细胞调节许多实体瘤的生长和进展。新兴的研究表明，成纤维细胞分泌多种因子，使癌细胞成为耐药性。本文将探讨成纤维细胞分泌的可溶性因子如何作用于癌细胞，以提高癌细胞的存活和癌症干细胞的更新，有助于耐药癌症的发展。
Conventional and targeted chemotherapies remain integral strategies to treat solid tumors. Despite the large number of anti-cancer drugs available, chemotherapy does not completely eradicate disease. Disease recurrence and the growth of drug resistant tumors remain significant problems in anti-cancer treatment. To develop more effective treatment strategies, it is important to understand the underlying cellular and molecular mechanisms of drug resistance. It is generally accepted that cancer cells do not function alone, but evolve through interactions with the surrounding tumor microenvironment. As key cellular components of the tumor microenvironment, fibroblasts regulate the growth and progression of many solid tumors. Emerging studies demonstrate that fibroblasts secrete a multitude of factors that enable cancer cells to become drug resistant. This review will explore how fibroblast secretion of soluble factors act on cancer cells to enhance cancer cell survival and cancer stem cell renewal, contributing to the development of drug resistant cancer.