Integration of thermal and osmotic regulation of water homeostasis: the role of TRPV channels.
Integration of thermal and osmotic regulation of water homeostasis: the role of TRPV channels.
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DOI：
10.1152/ajpregu.00270.2013
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
C. Sladek;A. Johnson
中科院分区：
文献类型：
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作者：
C. Sladek;A. Johnson
维持体内水分的平衡对于防止体温过高至关重要，因为蒸发冷却是消散多余体温的最有效手段。水的体内平衡是通过肾脏调节水的摄入和流失来实现的。前者是通过口渴的感觉来实现的，口渴的感觉促使水的获取，而后者是通过加压素的抗利尿作用来调节的。细胞外液的渗透压增加以及血压和/或血容量的降低刺激血管加压素分泌和口渴，这些信号是由与防止体温过高所需的过量蒸发失水相关的水消耗引起的。此外，它们还受到体温升高的刺激。本文综述了热敏感性和机械敏感性瞬时受体电位香草酸（TRPV）离子通道家族在口渴和加压素分泌的热渗透调节中的作用及其分子机制。
Maintenance of body water homeostasis is critical for preventing hyperthermia, because evaporative cooling is the most efficient means of dissipating excess body heat. Water homeostasis is achieved by regulation of water intake and water loss by the kidneys. The former is achieved by sensations of thirst that motivate water acquisition, whereas the latter is regulated by the antidiuretic action of vasopressin. Vasopressin secretion and thirst are stimulated by increases in the osmolality of the extracellular fluid as well as decreases in blood pressure and/or blood volume, signals that are precipitated by water depletion associated with the excess evaporative water loss required to prevent hyperthermia. In addition, they are stimulated by increases in body temperature. The sites and molecular mechanisms involved in integrating thermal and osmotic regulation of thirst and vasopressin secretion are reviewed here with a focus on the role of the thermal and mechanosensitive transient receptor potential-vanilloid (TRPV) family of ion channels.