Antiepileptic drugs and liver disease
Antiepileptic drugs and liver disease
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DOI：
10.1016/j.seizure.2005.12.009
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发表时间：
2006-04-01
影响因子：
3
通讯作者：
Siddiqi, ZA
中科院分区：
文献类型：
--
作者：
Ahmed, SN;Siddiqi, ZA
Antiepileptic drugs (AEDs) are no longer restricted to the treatment of epilepsy. These are widely used in a broad spectrum of psychiatric and neurological disorders. Liver plays a major role in the metabolism of a majority of these drugs. Hepatotoxicity is rare, but a real concern when initiating therapy. Likewise, liver disease can adversely affect the biotransformation of some of these drugs.This manuscript addresses the significance of elevated liver enzymes associated with AED use, the rote of therapeutic drug monitoring, pharmacokinetics during liver disease and potential risk of hepatotoxicity. (c) 2006 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
