High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Clinical Patients with Pancreatic Cancer
High STMN1 Expression Is Associated with Tumor Differentiation and Metastasis in Clinical Patients with Pancreatic Cancer
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DOI：
10.21873/anticanres.12307
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发表时间：
2018-02-01
影响因子：
2
通讯作者：
Shirabe, Ken
中科院分区：
文献类型：
--
作者：
Suzuki, Kazunobu;Watanabe, Akira;Shirabe, Ken
背景：胰腺导管腺癌（PDAC）是全世界癌症相关死亡的主要原因。据报道，Stathmin 1（STMN 1）抑制可降低细胞活力和迁移潜力。然而，没有以前的研究已经解决是否STMN 1过表达与PDAC的恶性潜能。材料与方法：为了阐明STMN 1在PDAC中的临床意义，采用免疫组织化学方法检测了104例PDAC中STMN 1的表达。此外，我们评估了高表达STMN 1的胰腺癌细胞系Suit 2细胞的增殖潜力和迁移能力。结果：PDAC中STMN 1的表达水平明显高于相应癌旁组织。STMN 1高表达的PDAC患者（n=29）与STMN 1低表达的PDAC患者（n=75）相比，与低分化和远处转移显著相关。Suit 2-STMN 1细胞的增殖率和迁移能力均高于Suit 2-mock细胞。结论：STMN 1评估可能是一个有用的进展标志物，STMN 1可能是PDAC靶向治疗的一个有希望的候选者。
Background: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths worldwide. Stathmin 1 (STMN1) suppression was reported to reduce cellular viability and migration potential. However, no previous studies have addressed whether STMN1 overexpression is associated with malignant potential in PDAC. Materials and Methods: To clarify the clinical significance of STMN1 in PDAC, the STMN1 expression in 104 PDAC samples was evaluated by immunohistochemistry. Moreover, we evaluated the proliferative potential and migration ability of pancreatic cancer cell line Suit2 cells highly expressing STMN1. Results: Cytoplasmic STMN1 were higher levels in PDAC than in corresponding non-cancerous tissues. PDAC patients with high STMN1 (n=29) were significantly associated with poor differentiation and distant metastasis compared to those with low STMN1 (n=75). The proliferation rates and migration ability in Suit2-STMN1 were higher than those of Suit2-mock. Conclusion: STMN1 evaluation could be a useful progression marker, and STMN1 may be a promising candidate for targeted therapies in PDAC.