Implantable Technologies - Peptides and Small Molecules Drug Delivery
Implantable Technologies - Peptides and Small Molecules Drug Delivery
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植入技术 - 肽和小分子药物输送
DOI：
10.1039/9781839164958-00252
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Qi S
中科院分区：
文献类型：
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作者：
Qi S
随着基因组学和临床诊断的快速发展，个性化医疗正在走向成熟。使用三维（3D）打印来定制药物、植入物和手术指南，以满足每位患者的需求，在实现个性化治疗方面发挥着重要作用。本章介绍了常见的3D打印方法，然后回顾了目前在植入物制造中使用3D打印的发展。3D打印手术导板的临床应用，以及术前和术中模型比3D打印植入物更常见。在3D打印的帮助下，非常规和复杂的程序可以准确和物理地概念化和计划，以提高手术的成功率。因此，3D打印已经被用于手术计划、2-4手术指南打印、患者特定器械（PSI）、5-7特定病例植入物（如钢板和关节成形术部件）的制造8-10以及患者和外科医生的教育目的11（图11.1）。然而，在技术和监管方面，将3D打印扩展到按需植入物的常规制造仍在发展中。
With the rapid emerging advancements in genomics and clinical diagnostics, personalized medicine is stepping into maturity. Using three-dimensional (3D) printing to custom make medicine, implants and surgical guides tailored for each patient's needs plays an important part in enabling personalized treatments. This chapter provides an introduction to the common 3D printing methods followed by a review of the current development of using 3D printing in implant manufacturing. The clinical uses of 3D printed surgical guides, as well as preoperative and interoperative models are far more common than 3D printed implants. With the aid of 3D printing, non-routine and complex procedures can be accurately and physically conceptualised and planned to increase the success rate of the surgery. 1 Therefore, the adoption of 3D printing has already been undertaken for surgical planning, 2–4 surgical guides printing, patientspecific instrumentation (PSI), 5–7 the manufacture of case-specific implants (eg plates and arthroplasty components) 8–10 and for education purposes of patients and surgeons 11 (Figure 11.1). However, the extended use of 3D printing to routine fabrication of implants on demand is still under development, in both technical and regulatory aspects.