Elevation of Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999 to species rank as Mycobacterium caprae comb. nov., sp. nov.
Elevation of Mycobacterium tuberculosis subsp. caprae Aranaz et al. 1999 to species rank as Mycobacterium caprae comb. nov., sp. nov.
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DOI：
10.1099/ijs.0.02532-0
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发表时间：
2003-11-01
影响因子：
2.8
通讯作者：
Domínguez, L
中科院分区：
文献类型：
--
作者：
Aranaz, A;Cousins, D;Domínguez, L
从山羊中回收的结核分枝杆菌复合体分离物最初被分类为结核分枝杆菌亚种。卡普拉;然而，该亚种最近被重新分类为牛分枝杆菌亚种。卡普拉。除了生化（对吡嗪酰胺敏感）和流行病学特征外，结核分枝杆菌复合体中这一不寻常成员的菌株还表现出 pncA、oxyR、katG 和 gyrA 基因多态性的特殊组合。对这些菌株中gyrB基因的序列分析揭示了在结核分枝杆菌复合体的其他成员中未发现的特殊核苷酸取代，其可用于区分山羊分枝杆菌菌株与牛分枝杆菌和结核分枝杆菌复合体的其他成员。结核分枝杆菌亚种。现在卡普拉埃病似乎不仅限于西班牙山羊，因为这种生物体的菌株已从牛、野猪和猪中分离出来。法国、奥地利和德国也有报道称其发生。两项基于差异区域存在/不存在的结核分枝杆菌复合体进化研究表明，山羊分离群（或其祖先）比牛分枝杆菌（或其祖先）更古老。这些发现强化了最初的观点，即山羊分枝杆菌菌株是结核分枝杆菌复合体的一个分类单元，独立于牛分枝杆菌。在结核分枝杆菌复合体现有命名法的当前背景下，建议将结核分枝杆菌亚种命名为结核分枝杆菌亚种。山羊分枝杆菌被提升到物种状态，如山羊分枝杆菌梳。十一月，SP。十一月
Mycobacterium tuberculosis complex isolates recovered from goats were originally classified as Mycobacterium tuberculosis subsp. caprae; however, this subspecies was recently reclassified as Mycobacterium bovis subsp. caprae. Besides biochemical (sensitivity to pyrazinamide) and epidemiological features, strains of this unusual member of the M. tuberculosis complex show a special combination of pncA, oxyR, katG and gyrA gene polymorphisms. Sequence analysis of the gyrB gene in these strains reveals special nucleotide substitutions not found in other members of the M. tuberculosis complex that can be used to differentiate caprine mycobacterial strains from M. bovis and other members of the M. tuberculosis complex. M. tuberculosis subsp. caprae now appears not to be restricted to Spanish goats, as strains of this organism have been isolated from cattle, wild boar and pigs. Its occurrence has also been reported in France, Austria and Germany. Two studies on the evolution of the M. tuberculosis complex based on the presence/absence of regions of difference have shown that the group of caprine isolates (or its ancestor) is older than M. bovis (or its ancestor). These findings reinforce the original suggestion that the caprine mycobacterial strains are a taxon of the M. tuberculosis complex, independent of M. bovis. Within the current context of the existing nomenclature of the M. tuberculosis complex, it is proposed that M. tuberculosis subsp. caprae be elevated to species status, as Mycobacterium caprae comb. nov., sp. nov.