Pelvic body composition measurements by quantitative computed tomography: Association with recent hip fracture
Pelvic body composition measurements by quantitative computed tomography: Association with recent hip fracture
复制标题
DOI：
10.1016/j.bone.2007.12.002
复制
发表时间：
2008-04-01
期刊：
影响因子：
4.1
通讯作者：
Cheng, X.
中科院分区：
文献类型：
--
作者：
Lang, T.;Koyama, A.;Cheng, X.
简介：老年人皮下脂肪减少、肌肉横截面积（CSA）减少和肌肉肥胖增加与身体功能下降和残疾有关，但关于这些组织变化与髋部骨折的关系的信息很少。因此，我们比较了髋部骨折妇女与年龄匹配的对照组的身体组成测量，使用髋部的定量计算机断层扫描（QCT）成像来表征总肥胖、肌肉CSA和肌肉衰减系数（肥胖的测量）。材料和方法：45名中国髋部骨折女性（平均年龄74.71 ± 5.94岁）与66名健康对照组（平均年龄70.70 ± 4.66岁）进行了比较。对髋关节QCT扫描进行分析，以计算总脂肪CSA以及CT扫描视野中肌群（包括髋关节伸肌、外展肌、内收肌和屈肌）的CSA和衰减值。根据QCT图像估计股骨总面积BMD（aBMD）。在调整年龄、身高、BMI和aBMD后，采用Logistic回归分析比较骨折受试者和对照者的身体成分指标。受试者工作曲线（ROC）分析确定aBMD和身体成分的组合是否比单独aBMD具有更高的曲线下面积（AUC）。
Introduction: Loss of subcutaneous fat, decreased muscle cross-sectional area (CSA) and increased muscle adiposity are related to declining physical function and disability in the elderly, but there is little information about the relationship of these tissue changes to hip fracture. Thus we have compared body composition measures in women with hip fractures to age-matched controls, using quantitative computed tomography (QCT) imaging of the hip to characterize total adiposity, muscle CSA and muscle attenuation coefficient, a measure of adiposity.Materials and methods: 45 Chinese women (mean age 74.71 +/- 5.94) with hip fractures were compared to 66 healthy control subjects (mean age 70.70 +/- 4.66). Hip QCT scans were analyzed to compute total adipose CSA as well as CSA and attenuation values of muscle groups in the CT scan field of view, including hip extensors, abductors, adductors and flexors. The total femur areal BMD (aBMD) was estimated from the QCT images. Logistic regression was employed to compare body composition measures between fracture subjects and controls after adjustment for age, height, BMI and aBMD. Receiver-operator curve (ROC) analyses determined whether combinations of aBMD and body composition had higher area under curve (AUC) than aBMD alone.Results and conclusions: Fracture subjects had lower fat CSA (p