Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats
Exercise ameliorates depression-like behavior and increases hippocampal BDNF level in ovariectomized rats
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运动可改善卵巢切除大鼠的抑郁样行为并增加海马 BDNF 水平
DOI：
10.1016/j.neulet.2014.04.053
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发表时间：
2014-06-01
影响因子：
2.5
通讯作者：
Liu, Yu
中科院分区：
文献类型：
--
作者：
Lu, Jianqiang;Xu, Yongjun;Liu, Yu
本研究的目的是调查运动是否可以改善雌激素缺乏引起的抑郁样行为。鉴于包括海马和前额叶皮层在内的许多大脑区域的脑源性神经营养因子（BDNF）水平下降与雌激素缺乏引起的抑郁样行为有关，我们还确定了运动是否会影响海马和前额叶皮层（PFC）中的 BDNF 及其受体水平。研究发现，卵巢切除术 (OVX) 导致大鼠抑郁样行为增加，海马 BDNF 水平降低，但 PFC 中却没有。海马和 PFC 中高亲和力 BDNF 受体 TrkB 的表达不受 OVX 影响。 17 β-雌二醇 (E-2) 治疗可改善 OVX 大鼠的抑郁样行为并增加海马 BDNF 水平。血清E2水平与抑郁样行为呈负相关，与海马BDNF水平呈正相关。运动可改善 OVX 大鼠的抑郁样行为，提高血清 E-2 水平和海马 BDNF 水平。 E-2水平升高与BDNF水平无关，但与运动大鼠的一些行为相关。我们的结果表明，E-2 维持海马体中的 BDNF，从而改善抑郁样行为。运动改善 OVX 大鼠抑郁样行为的部分原因是血清 E-2 水平升高。 (C) 2014 年作者。由 Elsevier Ireland Ltd 出版。这是一篇遵循 CC BY-NC-ND 许可的开放获取文章。
The aims of the present study were to investigate whether exercise can improve the depression-like behavior caused by estrogen deficiency. Given that decreased level of brain-derived neurotrophic factor (BDNF) in many brain areas including hippocampus and prefrontal cortex is associated with estrogen deficiency-induced depression-like behavior, we also determined whether exercise affects the levels of BDNF and its receptor in hippocampus and prefrontal cortex (PFC). It was found that ovariectomy (OVX) caused an increase in depression-like behavior in rats and a decrease in BDNF level in hippocampus but not in PFC. The expression of TrkB, a high affinity BDNF receptor in hippocampus and PFC was not affected by OVX. 17 beta-estradiol (E-2) treatment ameliorated depression-like behavior and increased BDNF level in hippocampus in OVX rats. Serum E2 level inversely correlated to depression-like behavior and positively correlated to BDNF level in hippocampus. Exercise ameliorated depression-like behavior, increased serum E-2 level and BDNF level in hippocampus in OVX rats. The increased E-2 level did not correlate to BDNF level but correlated with some of the behaviors in the rats subjected to exercise. Our results suggested that E-2 maintains BDNF in hippocampus, thereby ameliorating depression-like behavior. Exercise amelioration of depression-like behavior in OVX rats is partly due to increased serum E-2 level. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license.