THE ROLE OF NEURON DEATH IN THE DEVELOPMENT OF THE GENDER DIFFERENCE IN THE NUMBER OF NEURONS IN THE RAT SUPERIOR CERVICAL-GANGLION
THE ROLE OF NEURON DEATH IN THE DEVELOPMENT OF THE GENDER DIFFERENCE IN THE NUMBER OF NEURONS IN THE RAT SUPERIOR CERVICAL-GANGLION
复制标题
DOI：
10.1016/0736-5748(87)90005-0
复制
发表时间：
1987-01-01
影响因子：
1.8
通讯作者：
SMOLEN, AJ
中科院分区：
文献类型：
--
作者：
WRIGHT, LL;SMOLEN, AJ
成年雄性大鼠的上级颈神经节比成年雌性大鼠有更多的神经元。这种差异出现在出生后的前两周，显然与围产期循环睾酮水平有关。新生大鼠在出生后第一周暴露于睾酮或雌二醇导致出生后15、30或60天观察到的上级颈神经节中神经元数量增加。进行本研究以确定所观察到的神经元的增加是由于神经元增殖的增加还是由于神经元死亡的减少。放射自显影研究的结果表明，出生后暴露于雌二醇后，没有证据表明神经元增殖增强，但确实显示出生前标记的细胞群存活增加。在上级颈神经节中的退化细胞的计数显示，在正常神经元退化的高峰期，在出生后第5天，17-β-雌二醇或丙酸睾酮处理的动物比注射载体的同窝对照具有显著更少的退化的上级颈神经节细胞。此外，在第5天，溶媒注射雌性动物的退化细胞多于溶媒注射雄性动物。总之，这些结果提供了强有力的证据，即新生儿暴露于雌二醇后观察到的上级颈神经节神经元的增加导致发育神经元死亡的减少。
Adult male rats have more neurons in their superior cervical ganglia than do adult females. This difference arises over the first two postnatal weeks, and is apparently related to perinatal levels of circulating testosterone. Exposure of neonatal rats to testosterone of estradiol during the first postnatal weeks results in an increase in the number of neurons in the superior cervical ganglion seen at 15, 30 or 60 days postnatally. The present studies were undertaken to determine whether this observed increase in neurons is due to an increase in neuronal proliferation or to a decrease in neuronal death. Results of autoradiographic studies how no evidence of enhanced neuronal proliferation following postnatal exposure to estradiol, but do show an increased survival of a prenatally labeled population of cells. Counts of degenerating cells in the superior cervical ganglion show that during the peak period of normal neuronal degeneration, on postnatal day 5, 17-.beta.-estradiol or testosterone propionate treated animals have significantly fewer degenerating superior cervical ganglion cells than do vehicle-injected littermate controls. In addition, vehicle-injected females have more degenerating cells on day 5 than do vehicle-injected males. Taken together these results provide strong evidence that the increase in superior cervical ganglion neurons seen after neonatal exposure to estradiol results form a reduction in developmental neuron death.