Molecular heterogeneity of colorectal cancer: Implications for cancer control
Molecular heterogeneity of colorectal cancer: Implications for cancer control
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DOI：
10.1016/j.suronc.2007.10.039
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发表时间：
2007-12-01
影响因子：
2.3
通讯作者：
Jass, Jeremy R.
中科院分区：
文献类型：
--
作者：
Jass, Jeremy R.
结直肠癌（CRC）是一种多途径疾病。CRC分类的分子方法利用：（1）遗传不稳定性的类型，特别是微卫星不稳定性（MSI）与稳定（MSS），和（2）DNA甲基化或CpG岛甲基化表型（CIMP）的存在。MSS/CIMP-neg亚群通过经典的腺瘤-癌序列进化，而MSI/CIMP-pos和MSS/CIMP-pos亚群通过最近公认的“锯齿状途径”进化。本综述将表明，存在两个或两个以上的独立途径，以CRC是相关的癌症预防。特别是，新的战略，检测和管理无蒂锯齿状息肉将需要开发和评估。(c)2007爱思唯尔有限公司保留所有权利。
Colorectal cancer (CRC) is a multi-pathway disease. A molecular approach to the classification of CRC utilises: (1) the type of genetic instability, specifically microsatellite instability (MSI) versus stable (MSS), and (2) the presence of DNA methylation or the CpG island methylator phenotype (CIMP). The MSS/CIMP-neg subset evolves through the classical adenoma-carcinoma sequence while the MSI/CIMP-pos and MSS/CIMP-pos subsets evolve through the recently recognised 'serrated pathway'. This review will show that the existence of two or more independent pathways to CRC is relevant to cancer prevention. In particular, new strategies for detecting and managing sessile serrated polyps will need to be developed and evaluated. (c) 2007 Elsevier Ltd. All rights reserved.