Association between fish consumption and nephropathy in American Indians--the Strong Heart Study.
Association between fish consumption and nephropathy in American Indians--the Strong Heart Study.
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DOI：
10.1053/j.jrn.2011.03.003
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Adler AI
中科院分区：
文献类型：
--
作者：
Lee CC;Howard BV;Mete M;Wang H;Jolly S;Adler AI
本研究调查了美洲印第安人吃鱼和肾病之间的关系。在强心脏研究的家庭队列中，我们调查了2261名参与者，在2001年至2003年间进行了基线检查，并在2006年至2008年间进行了随访检查。平均随访时间为5.4年。我们将鱼类消费定义为金枪鱼、炸鱼和非炸鱼的膳食摄入量的总和，这些摄入量来自一份经过验证的食物频率问卷。肾病定义为微量白蛋白尿（尿白蛋白-肌酐比值[ACR]: 30 ~ 299 mg/g）、大量白蛋白尿（尿ACR:≥300 mg/g）或肾小球滤过率<60 mL/min/1.73 m2。使用回归模型，我们检查了基线时测量的鱼摄入量与随访时出现的肾病、蛋白尿或肾脏损害的两种结果之间的关系，以及基线和随访检查之间尿ACR的变化或肾小球滤过率的估计。微量白蛋白尿、大量白蛋白尿和肾脏损害的患病率分别为13%、3%和4%。参与者吃的鱼主要是油炸的。在调整了人口统计学、临床、生活方式和饮食因素后，我们发现食用鱼类与任何肾病指标之间没有关联。在美国印第安人中，以炸鱼为主的饮食摄入与较低的肾病风险无关。
The present study examined the association between fish consumption and nephropathy in American Indians. In the family cohort of the Strong Heart Study, we investigated 2,261 participants with baseline examination between 2001 and 2003 and follow-up examination between 2006 and 2008. The average follow-up period was 5.4 years. We defined fish consumption as the sum of dietary intake of tuna, fried fish, and nonfried fish obtained from a validated food frequency questionnaire. Nephropathy was defined as microalbuminuria (urinary albumin–creatinine ratio [ACR]: 30 to 299 mg/g), macroalbuminuria (urinary ACR: ≥300 mg/g), or an estimated glomerular filtration rate of <60 mL/min/1.73 m2. Using regression models, we examined the association between fish consumption measured at baseline and 2 outcomes in nephropathy present at follow-up, albuminuria, or renal impairment, and change in urinary ACR or estimated glomerular filtration rate between baseline and follow-up examinations. The prevalence of microalbuminuria, macroalbuminuria, and renal impairment was 13%, 3%, and 4%, respectively. The fish items consumed by the participants were predominantly deep-fried. We found no associations between fish consumption and any measure of nephropathy after adjusting for demographic, clinical, lifestyle, and dietary factors. Dietary intake of predominantly fried fish was not associated with a lower risk of nephropathy in American Indians.