Quantitative susceptibility atlas construction in Montreal Neurological Institute space: towards histological-consistent iron-rich deep brain nucleus subregion identification
Quantitative susceptibility atlas construction in Montreal Neurological Institute space: towards histological-consistent iron-rich deep brain nucleus subregion identification
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蒙特利尔神经学研究所空间的定量磁化率图谱构建：实现组织学一致的富铁深部脑核亚区域识别
DOI：
10.1007/s00429-022-02547-1
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发表时间：
2022-08-29
影响因子：
3.1
通讯作者：
Zhang, Yuyao
中科院分区：
文献类型：
--
作者：
He, Chenyu;Guan, Xiaojun;Zhang, Yuyao
脑深部富铁核团（DBN）参与多种运动、情绪和认知脑功能。DBN中的异常铁改变与多种神经和精神疾病密切相关。定量磁化率成像（QSM）提供了人脑组织磁化率的空间分布。与传统的结构成像相比，由于脑组织之间存在的磁化率差异，QSM在成像富铁DBN方面具有优势。在这项研究中，我们构建了一个蒙特利尔神经研究所（MNI）的空间无偏QSM人脑图谱，通过组明智的注册从100名健康受试者，年龄在19-29岁。图谱构建过程由多模态磁共振图像（MRI）融合的混合图像指导。我们将其命名为多模态融合磁化率（MuSus-100）图谱。高质量的磁化率图谱提供了富铁DBN与其周围环境之间的非凡图像对比。DBN及其与神经和精神病理学高度相关的子区域的Parcellation图然后基于在图像边界增强过程的协助下的图谱集手动标记。参照Schaltenbrand-Wahren立体定向图谱，将双侧丘脑划分为64个详细亚区。据我们所知，组织学一致的丘脑核包裹地图是第一次很好地定义在MNI空间。与强调DBN分割的现有图谱相比，新提出的图谱在准确性和鲁棒性方面都优于图谱引导的个体脑图像DBN分割任务。此外，我们应用建议的DBN parcellation地图进行详细的识别帕金森病（PD）患者的皮质下核的病理相关的铁含量的变化。我们设想MuSus-100图谱可以在提高DBN分割的准确性方面发挥至关重要的作用，用于神经和精神疾病进展的研究，也有助于脑深部电刺激手术中的靶点规划。
Iron-rich deep brain nuclei (DBN) of the human brain are involved in various motoric, emotional and cognitive brain functions. The abnormal iron alterations in the DBN are closely associated with multiple neurological and psychiatric diseases. Quantitative susceptibility mapping (QSM) provides the spatial distribution of the magnetic susceptibility of human brain tissues. Compared to traditional structural imaging, QSM provides superiority for imaging the iron-rich DBN owing to the susceptibility difference existing between brain tissues. In this study, we constructed a Montreal Neurological Institute (MNI) space unbiased QSM human brain atlas via group-wise registration from 100 healthy subjects aged 19-29 years. The atlas construction process was guided by hybrid images that were fused from multi-modal magnetic resonance images (MRI). We named it as Multi-modal-fused magnetic Susceptibility (MuSus-100) atlas. The high-quality susceptibility atlas provides extraordinary image contrast between iron-rich DBN with their surroundings. Parcellation maps of DBN and their subregions that are highly related to neurological and psychiatric pathology were then manually labeled based on the atlas set with the assistance of an image border-enhancement process. Especially, the bilateral thalamus was delineated into 64 detailed subregions referring to the Schaltenbrand-Wahren stereotactic atlas. To our best knowledge, the histological-consistent thalamic nucleus parcellation map is well defined for the first time in the MNI space. Compared with existing atlases that emphasizing DBN parcellation, the newly proposed atlas outperforms on the task of atlas-guided individual brain image DBN segmentation both in accuracy and robustness. Moreover, we applied the proposed DBN parcellation map to conduct detailed identification of the pathology-related iron content alterations in subcortical nuclei for Parkinson's Disease (PD) patients. We envision that the MuSus-100 atlas can play a crucial role in improving the accuracy of DBN segmentation for the research of neurological and psychiatric disease progress and also be helpful for target planning in deep brain stimulation surgery.