Aerosol deposition in the extrathoracic region
Aerosol deposition in the extrathoracic region
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DOI：
10.1080/02786820300906
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发表时间：
2003-08-01
影响因子：
5.2
通讯作者：
Cheng, YS
中科院分区：
文献类型：
--
作者：
Cheng, YS
胸外区域，包括鼻和口腔通道、咽和喉，是人体呼吸道的入口，也是防止吸入空气污染物的第一道防线。对胸部区域沉积的估计是基于人类志愿者获得的数据，这些数据显示，在类似的实验条件下，沉积量存在很大差异。在过去的十年中，物理模型和计算流体动力学模拟的研究已经提高了对沉积机制的理解，并显示了气溶胶沉积与气道几何形状的一些关联。这些信息已被分析，以改善沉积方程，其中包括特征气道尺寸，以解决鼻呼吸过程中沉积的受试者间变异性。鼻和口气道中的沉积对于>0.5 μ m的颗粒由惯性机制控制，对于颗粒由扩散机制控制
The extrathoracic region, including the nasal and oral passages, pharynx, and larynx, is the entrance to the human respiratory tract and the first line of defense against inhaled air pollutants. Estimates of regional deposition in the thoracic region are based on data obtained with human volunteers, and that data showed great variability in the magnitude of deposition under similar experimental conditions. In the past decade, studies with physical casts and computational fluid dynamic simulation have improved upon the understanding of deposition mechanisms and have shown some association of aerosol deposition with airway geometry. This information has been analyzed to improve deposition equations, which incorporate characteristic airway dimensions to address intersubject variability of deposition during nasal breathing. Deposition in the nasal and oral airways is dominated by the inertial mechanism for particles >0.5 mum and by the diffusion mechanism for particles