MicroRNA and long noncoding RNA involvement in gout and prospects for treatment
MicroRNA and long noncoding RNA involvement in gout and prospects for treatment
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MicroRNA 和长链非编码 RNA 参与痛风及其治疗前景
DOI：
10.1016/j.intimp.2020.106842
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发表时间：
2020-10-01
影响因子：
5.6
通讯作者：
Kong, Ling-Yi
中科院分区：
文献类型：
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作者：
Xu, Yi-Ting;Leng, Ying-Rong;Kong, Ling-Yi
MicroRNA (miRNA) 和长非编码 RNA (lncRNA) 都是非编码 RNA。它们已被证明参与多种人类炎症性疾病的调节，可以作为疾病诊断和预后的生物标志物，甚至可以开发成新药。痛风是一种由尿酸钠晶体（MSU）沉积在关节引起的关节炎疾病，可导致急性炎症并损害邻近组织。最近的研究表明 miRNA 和 lncRNA 介导痛风的进展。本文从痛风的发病机制，包括高尿酸血症、MSU沉积、急性痛风性关节炎和痛风性骨质侵蚀等方面入手，综述了miRNA和lncRNA在痛风发病过程中的作用以及miRNA和lncRNA在痛风中可能的治疗靶点。
MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are both types of noncoding RNA. They have been demonstrated to be involved in the regulation of various human inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis, and even be developed into new drugs. Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue. Recent studies have shown that miRNAs and lncRNAs mediate the progress of gout. Based on the pathogenesis of gout, including hyperuricemia, MSU deposition, acute gouty arthritis and gouty bone erosion, this paper reviewed the role of miRNAs and lncRNAs in the processes and the possible therapeutic targets of miRNAs and lncRNAs in gout.