Sleep stage transitions in chronic fatigue syndrome patients with or without fibromyalgia.
Sleep stage transitions in chronic fatigue syndrome patients with or without fibromyalgia.
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患有或不患有纤维肌痛的慢性疲劳综合征患者的睡眠阶段转变。
DOI：
10.1109/iembs.2010.5626478
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Yamamoto,Yoshiharu
中科院分区：
文献类型：
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作者：
Kishi,Akifumi;Natelson,BenjaminH;Togo,Fumiharu;Struzik,ZbigniewR;Rapoport,DavidM;Yamamoto,Yoshiharu
慢性疲劳综合征（CFS）和纤维肌痛（FM）是医学上无法解释的疾病，它们有相当多的重叠症状，包括睡眠相关的投诉。然而，这两种情况之间的差异已经被报道，我们假设，最近引起科学兴趣的睡眠动态方面在两组患者中是不同的。因此，我们研究CFS患者的睡眠阶段之间的转换概率与FM或没有。受试者为26名健康对照，14名CFS患者无FM（CFS单独）和12名CFS患者FM（CFS+FM）-所有女性。我们研究了睡眠阶段之间的转换概率（清醒，REM睡眠和阶段I，阶段II和慢波睡眠（阶段III+IV））。我们发现，从REM睡眠到清醒的过渡概率在单独的CFS中比在对照组中显著更大;我们先前已经报道了这种睡眠中断作为单独的CFS的特定睡眠问题[Kishi等人，2008年]。从清醒，REM睡眠和第一阶段过渡到第二阶段的概率，以及从慢波睡眠到第一阶段的概率，CFS+FM组显著高于对照组;前者可能表明CFS+FM的睡眠压力增加，后者可能是CFS+FM的特定睡眠问题。这些结果表明，CFS和FM是与不同的睡眠调节问题相关的不同疾病。
Chronic fatigue syndrome (CFS) and fibromyalgia (FM) are medically unexplained conditions that share considerable overlapping symptoms, including sleep-related complaints. However, differences between the two conditions have been reported, and we hypothesized that dynamic aspects of sleep, recently attracting scientific interests, would be different in the two groups of patients. We thus study transition probabilities between sleep stages of CFS patients with or without FM. Subjects were 26 healthy controls, 14 CFS patients without FM (CFS alone) and 12 CFS patients with FM (CFS+FM) - all women. We studied transition probabilities between sleep stages (waking, REM sleep and Stage I, Stage II and slow-wave sleep (Stage III+IV)). We found that probabilities of transition from REM sleep to waking were significantly greater in CFS alone than in controls; we have reported previously this sleep disruption as the specific sleep problem for CFS alone [Kishi et al., 2008]. Probabilities of transitions from waking, REM sleep and Stage I to Stage II, and those from slow-wave sleep to Stage I, were significantly greater in CFS+FM than in controls; the former might indicate increased sleep pressure in CFS+FM and the latter may be the specific sleep problem of CFS+FM. These results suggest that CFS and FM are different illnesses associated with different problems of sleep regulation.