The zigzag model of plant-microbe interactions: is it time to move on?
The zigzag model of plant-microbe interactions: is it time to move on?
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DOI：
10.1111/mpp.12210
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发表时间：
2014-12-01
影响因子：
4.9
通讯作者：
Birch, Paul R. J.
中科院分区：
文献类型：
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作者：
Pritchard, Leighton;Birch, Paul R. J.
2006年，Jones和Dangl提出了一个简单的植物-病原体相互作用的共同进化模型，称为“zigzag”模型，它包括植物免疫系统的两个分支（Jones和Dangl，2006）。第一个分支识别由许多种类的微生物共享的保守分子（病原体相关或微生物相关分子模式，PAMP或MAMP），并且现在被称为模式触发免疫（PTI）。第二个分支识别并响应称为效应子的毒力因子，在该模型中，该效应子用于抑制PTI。这个分支称为效应子触发免疫（ETI）。该模型已经抓住了植物病理学研究人员和学生的想象力，并已被证明是植物病原体相互作用的主要概念的一个强大的传送器。八年过去了，我们重新审视这个模型，考虑它是否符合预期目的，以及如何建立一个模型框架来激励未来植物-微生物相互作用领域的研究人员。
In 2006, Jones and Dangl proposed a simple coevolutionary model of plant–pathogen interactions, called the ‘zigzag’model, which encompasses two branches of the plant immune system (Jones and Dangl, 2006). The first branch recognizes conserved molecules shared by many classes of microbe (pathogen-associated or microbe-associated molecular patterns, PAMPs or MAMPs), and is now called pattern-triggered immunity (PTI). The second branch recognizes and responds to virulence factors termed effectors that, in the model, serve to suppress PTI. This branch is called effector-triggered immunity (ETI). The model has captured the imagination of plant pathology researchers and students alike, and has proved to be a powerful conveyor of the principal concepts in plant–pathogen interactions. Eight years on, we take a fresh look at the model to consider how well it fits its intended purpose, and how a model framework to inspire future researchers in the field of plant–microbe interactions might develop.