Tumor microenvironment-responsive MnSiO3-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy
Tumor microenvironment-responsive MnSiO3-Pt@BSA-Ce6 nanoplatform for synergistic catalysis-enhanced sonodynamic and chemodynamic cancer therapy
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肿瘤微环境响应型MnSiO_3-Pt@BSA-Ce6纳米平台用于协同催化增强声动力学和化学动力学癌症治疗
DOI：
10.1016/j.cclet.2021.12.096
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发表时间：
2022-05-20
影响因子：
9.1
通讯作者：
Lin, Jun
中科院分区：
文献类型：
--
作者：
Jiang, Fan;Yang, Chunzheng;Lin, Jun
与传统的光动力学疗法相比，超声（US）触发声动力学疗法（SDT）具有更深的穿透深度，在肿瘤治疗中具有广泛的应用前景。在此，一种新型的MnSiO 3-Pt（MP）纳米复合材料的组成MnSiO 3纳米球和贵金属Pt成功构建。通过牛血清白蛋白（BSA）和氯e6（Ce 6）的修饰，多功能纳米平台MnSiO 3-Pt@ BSA-Ce 6（MPBC）实现了磁共振成像（MRI）引导的协同SDT/CDT。在这种纳米平台中，声敏剂Ce 6可以在US照射下产生单线态氧（O-1（2））来杀死癌细胞。同时，负载Pt具有催化肿瘤微环境（TME）中过氧化氢（H2 O2）分解产生氧（O-2）的能力，可克服肿瘤缺氧，促进SDT诱导的O-1（2）产生。此外，MP在弱酸性和还原性TME中降解，导致Mn 2+的释放。释放的Mn ~（2+）不仅可用于MRI，而且可通过类Fenton反应产生用于CDT的羟基自由基（中心点OH）。多功能纳米平台MPBC生物安全性高，抗癌效果好，显示出巨大的生物应用潜力。(C)2022由Elsevier B. V.代表中国化学会和中国医学科学院药物研究所出版。
Compared with traditional photodynamic therapy (PDT), ultrasound (US) triggered sonodynamic therapy (SDT) has a wide application prospect in tumor therapy because of its deeper penetration depth. Herein, a novel MnSiO3-Pt (MP) nanocomposite composed of MnSiO3 nanosphere and noble metallic Pt was successfully constructed. After modification with bovine serum albumin (BSA) and chlorine e6 (Ce6), the multifunctional nanoplatform MnSiO3-Pt@BSA-Ce6 (MPBC) realized the magnetic resonance imaging (MRI)-guided synergetic SDT/chemodynamic therapy (CDT). In this nanoplatform, sonosensitizer Ce6 can generate singlet oxygen (O-1(2)) to kill cancer cells under US irradiation. Meanwhile, the loaded Pt has the ability to catalyze the decomposition of overexpressed hydrogen peroxide (H2O2) in tumor microenvironment (TME) to produce oxygen (O-2), which can conquer tumor hypoxia and promote the SDT-induced O-1(2) production. In addition, MP can degrade in mildly acidic and reductive TME, causing the release of Mn2+. The released Mn2+ not only can be used for MRI, but also can generate hydroxyl radical (center dot OH) for CDT by Fenton-like reaction. The multifunctional nanoplatform MPBC has high biological safety and good anticancer effect, which displays the great latent capacity in biological application. (C) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.