Physiologic control of two neurophysins in humans.
Physiologic control of two neurophysins in humans.
复制标题
人类两种神经生理素的生理控制。
DOI：
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发表时间：
1977
影响因子：
5.8
通讯作者：
C. Watson
中科院分区：
文献类型：
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作者：
A. G. Robinson;C. Haluszczak;J. Wilkins;A. Huellmantel;C. Watson
在人体生理活动和病理状态期间对两种人类神经生理素、尼古丁刺激的神经生理素（NSN）和雌激素刺激的神经生理素（ESN）进行了测定。 NSN 被认为与加压素有关，并且在一些受试者中由于容量不足、手术应激、低血压和高渗盐水输注而升高。尽管尿液浓缩，隔夜脱水并未升高 NSN。一些患有抗利尿激素分泌异常综合征的受试者的 NSN 升高，并且在测试时对水、酒精或尼古丁没有反应。 ESN was elevated during estrogen administration, in pregnancy, in newborns and in patients with cirrhosis. NSN was also acutely increased at parturition.这些数据支持 NSN 与加压素的关联，尽管只有在强烈刺激加压素释放时才会发现 NSN 的变化。 ESN 可能与催产素有关，但这一点的证明有待人类催产素生理学的了解。
Two human neurophysins, nicotine stimulated neurophysin (NSN), and estrogen stimulated neurophysin (ESN) were assayed during physiologic maneuvers and pathologic states in man. NSN is thought to be associated with vasopressin and was elevated in some subjects by volume depletion, surgical stress, hypotension and hypertonic saline infusion. Overnight dehydration did not elevate NSN in spite of urinary concentration. NSN was elevated in some subjects with the syndrome of inappropriate secretion of antidiuretic hormone and when tested was unresponsive to administered water, alcohol or nicotine. ESN was elevated during estrogen administration, in pregnancy, in newborns and in patients with cirrhosis. NSN was also acutely increased at parturition. These data support the association of NSN with vasopressin although changes in NSN were found only with potent stimuli for vasopressin release. ESN may be associated with oxytocin but demonstration of this awaits knowledge of oxytocin physiology in humans.