The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage
The role of the coagulation cascade in brain edema formation after intracerebral hemorrhage
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DOI：
10.1007/bf01420301
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发表时间：
1996-01-01
影响因子：
2.4
通讯作者：
Hoff, JT
中科院分区：
文献类型：
--
作者：
Lee, KR;Betz, AL;Hoff, JT
凝血级联在脑出血引起的脑水肿形成中具有潜在作用。在这项研究中，血液和其他溶液被立体定向注射到大鼠的右侧基底神经节中。注射后24小时，测量脑水分和离子含量以确定脑水肿的量。脑内血液导致脑含水量增加。血块凝固后，将凝血酶抑制剂 N α-(2-萘磺酰基甘氨酰)-4-脒基-DL-苯丙氨酸哌啶 (α-NAPAP) 注入血肿，可减少脑内血肿周围的脑水肿量。抑制剂不会改变血块的实际大小。由纤维蛋白原、凝血酶和苯乙烯微球组成的人造凝块也会产生脑水肿。即使没有微球提供的质量效应，纤维蛋白凝块也会导致水肿形成。在所有这些模型中导致脑水肿产生的单一成分是凝血酶。水肿是响应纤维蛋白原独立途径而形成的。这些结果表明凝血级联与脑内血肿附近发生的脑水肿有关。
The coagulation cascade has a potential role in brain edema formation due to intracerebral hemorrhage. In this study blood and other solutions were injected stereotactically into the right basal ganglia in rats. Twenty-four hours following injection, brain water and ion contents were measured to determine the amount of brain edema. Intracerebral blood resulted in an increase in brain water content. The amount of brain edema surrounding the intracerebral hematoma was reduced by a thrombin inhibitor N alpha-(2-Naphthalenesulfonylglycyl)-4-amidino-DL-phenylalaninepiperidide, (alpha-NAPAP) infused into the hematoma after the clot had been allowed to solidify. The inhibitor did not alter the actual size of the clot mass. An artificial clot composed of fibrinogen, thrombin, and styrene microspheres also produced brain edema. A fibrin clot led to edema formation even in the absence of mass effect provided by the microspheres. The single component responsible for production of brain edema in all these models was thrombin. The edema was formed in response to a fibrinogen-independent pathway. These results indicate that the coagulation cascade is involved in brain edema that develops adjacent to an intracerebral hematoma.