Changes in oesophageal wall biomechanics after portal vein banding and variceal sclerotherapy measured by a new technique. An experimental study in rabbits.
Changes in oesophageal wall biomechanics after portal vein banding and variceal sclerotherapy measured by a new technique. An experimental study in rabbits.
复制标题
通过新技术测量门静脉束带和静脉曲张硬化治疗后食管壁生物力学的变化。
DOI：
10.1136/gut.29.12.1699
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发表时间：
1988
期刊：
影响因子：
24.5
通讯作者：
JENS CHRISTIAN Djurhuus
中科院分区：
文献类型：
--
作者：
Hans Gregersen;L. Jensen;JENS CHRISTIAN Djurhuus
使用四电极阻抗技术在兔子模型中研究了食管壁的生物力学特性。将一种特殊设计的探针引入食道，该探针的电极位于低压可膨胀绝缘乳胶球囊内。进行逐步充气和放气以分析食管顺应性和滞后性。将兔子分为三组：对照组、一组患有食管静脉曲张组和一组接受硬化疗法治疗的静脉曲张组。食管静脉曲张是在检查前五个月通过门静脉束带诱发的。与对照组相比，食管静脉曲张组的食管壁生物力学特性发生了一致的变化。顺应性显着降低，滞后现象减少。内窥镜硬化疗法将壁特性改变为与正常情况无法区分的模式。因此，生物力学壁特性的体内研究表明，患有静脉曲张的食管的扩张性显着丧失，并且当用内窥镜硬化疗法治疗静脉曲张时，壁扩张性恢复。
The biomechanical properties of the oesophageal wall were investigated in a rabbit model using a four electrode impedance technique. A specially designed probe with the electrodes inside a low pressure expandable insulating latex balloon was introduced in the oesophagus. Stepwise inflation and deflation was done for analysis of oesophageal compliance and hysteresis. The rabbits were allocated to three groups: a control group, one with oesophageal varices and one with varices which were treated by sclerotherapy. The oesophageal varices were induced by portal banding five months before the investigation. A uniform pattern of changes in the biomechanical properties of the oesophageal wall was seen in the group with oesophageal varices when compared with controls. The compliance was significantly decreased, and the hysteresis was lessened. Endoscopic sclerotherapy changed the wall properties to a pattern not distinguishable from normal. Thus, in vivo investigation of the biomechanical wall properties showed a significant loss of distensibility of the oesophagus with varices and restorement of the wall distensibility when the varices were treated with endoscopic sclerotherapy.