HIV and cervical cancer in Kenya
HIV and cervical cancer in Kenya
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DOI：
10.1016/s0020-7292(01)00560-4
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发表时间：
2002-01-01
影响因子：
3.8
通讯作者：
Temmerman, M
中科院分区：
文献类型：
--
作者：
Gichangi, P;De Vuyst, H;Temmerman, M
目的：确定艾滋病毒流行对肯尼亚浸润性宫颈癌的影响。方法：在肯雅塔国立医院(KNH)1989至1998年间被诊断为生殖道恶性肿瘤的3902名妇女中，85%患有浸润性宫颈癌。我们研究了9年的宫颈癌发病年龄和严重程度，当时全国艾滋病毒流行率从5%上升到5%-10%，再到10%-15%。结果：宫颈癌患者的发病年龄和严重程度均无明显变化。在118名(5%)接受艾滋病毒检测的妇女中，36名(31%)血清阳性。这些女性在分娩时比HIV阴性的女性年轻5岁。结论：肯尼亚艾滋病毒流行率增加两到三倍似乎对宫颈癌的发病率没有成比例的影响。然而，患有宫颈癌的艾滋病毒阳性妇女明显比艾滋病毒阴性妇女年轻得多。(C)2002年国际妇产科联合会。版权所有。
Objectives: To determine the effect of the HIV epidemic on invasive cervical cancer in Kenya. Methods: Of the 3902 women who were diagnosed with reproductive tract malignancies at Kenyatta National Hospital (KNH) from 1989 to 1998, 85% had invasive cervical cancer. Age at presentation and severity of cervical cancer were studied for a 9-year period when national HIV prevalence went from 5% to 5-10%, to 10-15%. Results: There was no significant change in either age at presentation or severity of cervical cancer. Of the 118 (5%) women who were tested for HIV, 36 (31%) were seropositive. These women were 5 years younger at presentation than HIV-negative women. Conclusions: A two- to three-fold increase in HIV prevalence in Kenya did not seem to have a proportional effect on the incidence of cervical cancer. Yet, HIV-positive women who presented with cervical cancer were significantly younger than HIV-negative women. (C) 2002 International Federation of Gynecology and Obstetrics. All rights reserved.