Mutagenic Activity of Acrolein in S. typhimurium and E. coli
Mutagenic Activity of Acrolein in S. typhimurium and E. coli
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DOI：
10.1002/(sici)1099-1263(199603)16:2
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发表时间：
1996-03
影响因子：
3.3
通讯作者：
R. A. Parent;H. Caravello;R. San
中科院分区：
文献类型：
--
作者：
R. A. Parent;H. Caravello;R. San
丙烯醛对7株鼠伤寒沙门菌和1株大肠杆菌进行了诱变活性检测。在没有S‐9激活和存在S‐9激活的情况下，当丙烯醛浓度分别高于33 μg和67 μg / plate时，细胞毒性明显。在无毒剂量水平下，鼠伤寒沙门氏菌菌株TA98和TA100以及大肠杆菌菌株WP2 uvrA具有诱变活性的证据。TA98和大肠杆菌对TA100的反应充其量是微弱的，但TA100在没有S‐9激活的情况下，在没有S‐9激活的情况下，在67 μg / S‐9激活的情况下，具有明显的阳性诱变活性。本研究结果表明丙烯醛在高度控制的条件下具有诱变性。
Acrolein was tested for mutagenic activity in seven strains of Salmonella typhimurium and one strain of Escherichia coli using a preincubation assay procedure. Cytotoxicity was evident at dosing levels above 33 and 67 μg acrolein per plate in the absence and presence of S‐9 activation, respectively. Evidence of mutagenic activity was seen at non‐toxic dosing levels in S. typhimurium strains TA98 and TA100 and E. coli strain WP2 uvrA. Responses in TA98 and E. coli were marginal at best, but a firm positive mutagenic activity was noted in TA100 at 20 μg per plate without S‐9 activation and at 67 μg per plate with S‐9 activation. The results of this study demonstrate the mutagenicity of acrolein under highly controlled conditions.