Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers
Application of enhanced stromal vascular fraction and fat grafting mixed with PRP in post-traumatic lower extremity ulcers
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DOI：
10.1016/j.scr.2010.11.003
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发表时间：
2011-03-01
影响因子：
1.2
通讯作者：
Orlandi, Augusto
中科院分区：
文献类型：
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作者：
Cervelli, Valerio;Gentile, Pietro;Orlandi, Augusto
背景作者介绍了他们在创伤后下肢溃疡再生手术中的经验，评价了与使用增强基质血管分数（e-SVF）和富血小板血浆脂肪移植（PRP）相关的效果。作者比较了两个对照组的结果。方法分析涉及20例患者，年龄在23至62岁之间的创伤后下肢溃疡。罗马“Tor Vergata”大学整形与重建外科的10例患者接受了e-SVF治疗，10例患者接受了脂肪移植+ PRP治疗。对照组10例，仅行刮宫术，并在溃疡床内应用透明质酸。第二对照组（n=10），仅用PRP治疗。结果作者表明，用e-SVF治疗的伤口愈合优于用透明质酸治疗的伤口。事实上，9.7周后，用e-SVF治疗的患者经历了97.9%+/- 1.5%的上皮再生，而第一对照组为87.8%+/- 4.4%（仅透明质酸; p < 0.05）。用PRP和脂肪移植治疗的患者也显示出上皮再生的改善;事实上，在9.7周后，他们经历了97.8%+/- 1.5%的上皮再生，而第二对照组为89.1%+/- 3.8%（仅PRP; p < 0.05）。据报道，e-SVF和PRP混合脂肪移植是两种治疗方法，证明改善患者创伤后肢体溃疡的愈合。结论所获得的结果证明了这些治疗方法的有效性，患者的满意度证实了结果的质量。(c)2010 Elsevier B. V.保留所有权利。
Background The authors presented their experience in regenerative surgery of post-traumatic lower extremity ulcers, evaluating the effects related to the use of Enhanced Stromal Vascular Fraction (e-SVF) and Fat Grafting with Platelet rich Plasma (PRP). The authors compared the results of two control groups.Method The analysis involved 20 patients aged between 23 to 62 years affected by post-traumatic lower extremity ulcers. 10 patients managed with e-SVF and 10 patients managed with Fat grafting + PRP in the Plastic and Reconstructive Surgery Department at "Tor Vergata" University Rome. Patients in the first control group (n=10), were treated only with curettage and application of hyaluronic acid in the bed of ulcers. Patients in the second control group (n=10), were treated only with PRP.Results The authors showed that wounds treated with e-SVF healed better than those treated with hyaluronic acid. In fact, after 9.7 weeks, patients treated with e-SVF underwent 97.9%+/- 1.5% reepithelialisation compared to 87.8%+/- 4.4% of the first control group (only hyaluronic acid; p < 0.05). Patients treated with PRP and fat grafting also showed an improvement in reepithelialisation; in fact after 9.7 weeks, they underwent a 97.8%+/- 1.5% reepithelialisation compared to 89.1%+/- 3.8% of the second control group (only PRP; p < 0.05). As reported e-SVF and PRP mixed with fat grafting were the two treatments evidencing improvement in the healing of patients post-traumatic extremity ulcers.Conclusions The results obtained proved the efficacy of these treatments, and the satisfaction of the patients confirmed the quality of the results. (c) 2010 Elsevier B.V. All rights reserved.