Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance:: The Maine-Syracuse study
Homocysteine, folate, and vitamins B6 and B12 blood levels in relation to cognitive performance:: The Maine-Syracuse study
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DOI：
10.1097/01.psy.0000221380.92521.51
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发表时间：
2006-07-01
影响因子：
3.3
通讯作者：
Bates, Christopher J.
中科院分区：
文献类型：
--
作者：
Elias, Merrill F.;Robbins, Michael A.;Bates, Christopher J.
目的：我们的目的是检验血浆同型半胱氨酸浓度(THcy)、tHcy辅助因子(叶酸、维生素B-6和B-12)和认知表现的多个领域之间的关系，并对可能的混杂因素进行统计调整，包括心血管疾病危险因素(CVD-RF)和心血管疾病(CVD)。方法：受试者为812名没有痴呆和中风的缅因州-锡拉丘兹研究参与者(58%为女性)。采用横断面设计和多元回归分析，空腹tHcy及其维生素辅因子(叶酸、B-6和B-12)浓度与认知成绩的多个领域相关。结果：在调整了年龄、教育程度、性别、种族和维生素后，tHcy与视觉空间组织、工作记忆、扫描跟踪和抽象推理呈负相关。在调整年龄、教育程度、性别、种族、心血管疾病-RF和心血管疾病后，也发现了同样的结果。维生素辅助因子与认知成绩呈正相关，但调整CVD-RF和CVD后，只有维生素B-6与多个认知领域相关。结论：tHcy与认知功能的多个领域的负相关不一定依赖于维生素水平、维生素缺乏、流行的CVD危险因素和显性CVD。血清叶酸、血清B-12和血浆B-6维生素浓度与认知表现呈正相关。研究其他可能的机制(例如，tHcy神经毒性)介导tHcy与认知功能的关系是重要的，同样重要的是检验叶酸、维生素B-6和维生素B-12维持认知功能的有效性的临床试验。
Objective: Our objective was to examine associations among plasma homocysteine concentrations (tHcy), the tHcy-cofactors (folate, vitamins B-6 and B-12), and multiple domains of cognitive performance, with statistical adjustment for possible confounds, including cardiovascular disease risk factors (CVD-RF) and cardiovascular disease (CVD). Methods: Subjects were 812 participants (58% women) of the Maine-Syracuse study who were free of dementia and stroke. Employing a cross-sectional design and multiple regression analyses, fasting concentrations of tHcy and its vitamin cofactors (folate, B-6 and B-12) were related to multiple domains of cognitive performance. Results: With adjustment for age, education, gender, ethnicity, and the vitamins, tHcy was inversely associated with visual-spatial organization, working memory, scanning-tracking, and abstract reasoning. The same results were found with adjustment for age, education, gender, ethnicity, CVD-RF, and CVD. Vitamin cofactors were positively related to cognitive performance, but with adjustment for CVD-RF and CVD, only vitamin B-6 was related to multiple cognitive domains. Conclusions: The inverse association of tHcy with multiple domains of cognitive functioning is not necessarily dependent on vitamin levels, vitamin deficiency, prevalent CVD risk factors, and manifest CVD. Serum folate, serum B-12, and plasma B-6 vitamin concentrations are positively associated with cognitive performance. Investigation of other possible mechanisms (e.g., tHcy neurotoxicity) mediating tHcy associations with cognitive performance is important, as are clinical trials examining the efficacy of folate, vitamin B-6, and vitamin B-12 for maintenance of cognitive functioning.