PATHWAYS OF THE EARLY PROPAGATION OF VIRULENT AND AVIRULENT RABIES STRAINS FROM THE EYE TO THE BRAIN
PATHWAYS OF THE EARLY PROPAGATION OF VIRULENT AND AVIRULENT RABIES STRAINS FROM THE EYE TO THE BRAIN
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DOI：
10.1128/jvi.55.1.158-162.1985
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发表时间：
1985-01-01
影响因子：
5.4
通讯作者：
FLAMAND, A
中科院分区：
文献类型：
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作者：
KUCERA, P;DOLIVO, M;FLAMAND, A
通过将病毒接种到眼前房来研究狂犬病病毒CVS株及其2种无毒力衍生物Av01和Av02对成年大鼠中枢神经系统的渗透。 CVS 穿透的主要部位是眼内副交感动眼纤维、顶盖前起源的视网膜纤维和眼神经的眼内纤维。突变菌株失去了侵入前两组纤维的能力，尽管它们对三叉神经系统的渗透并未受到损害。 CVS 菌株和突变体均不主要感染眼内肾上腺素能末梢和视神经。突变菌株能够感染晶状体，但 CVS 不能。这些结果表明胆碱能受体可能不是狂犬病病毒的唯一受体，狂犬病病毒通过逆行轴浆流在神经系统中传播。 CVS 菌株遍布整个大脑并最终传播回视网膜。突变体也渗透到大脑中，但感染速度很慢，涉及不同的大脑结构，并在 3 周内完全清除，这可能是因为有效的免疫反应。
Penetration of the CNS of the adult rat by the CVS strain of rabies virus and its 2 avirulent derivatives Av01 and Av02 was studied by inoculation of the virus into the anterior chamber of the eye. The primary sites of penetration of CVS were the intraocular parasympathetic oculomotor fibers, the retinopetal fibers of pretectal origin, and the intraocular fibers of the ophthalmic nerve. The mutant strains lost the capacity to invade the 2 former groups of fibers, although their penetration into the trigeminal system was not impaired. Neither strain CVS nor the mutants infected primarily the intraocular adrenergic terminals and the optic nerve. Mutant strains, but not CVS, were able to infect the lens. These results indicate that the cholinergic receptor may not be the only receptor for rabies virus and that rabies virus is conveyed in the nervous system by retrograde axoplasmic flow. Strain CVS spread throughout the brain and propagated eventually back to the retina. The mutants penetrated the brain as well, but the infection was slow, involved different cerebral structures, and cleared up completely in 3 wk, probably because of an efficient immune response.