Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
Macrophage-colony-stimulating factor selectively enhances macrophage scavenger receptor expression and function.
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DOI：
10.1084/jem.180.2.705
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发表时间：
1994-08-01
期刊：
影响因子：
--
通讯作者：
Gordon S
中科院分区：
文献类型：
--
作者：
de Villiers WJ;Fraser IP;Hughes DA;Doyle AG;Gordon S
巨噬细胞清道夫受体（MSR）活性的调节可能是动脉粥样硬化程度的重要决定因素。利用最近开发的鼠MSR单克隆抗体研究了巨噬细胞集落刺激因子（M-CSF）对这一通路的影响。M-CSF显著地和选择性地增加小鼠巨噬细胞中的MSR合成：在治疗后，受体似乎更稳定，并转移到主要的表面分布。在功能上，M-CSF在体外增强修饰的脂蛋白摄取并增加二价阳离子非依赖性粘附。这些结果表明一个合理的机制，即M-CSF的生产在动脉粥样硬化斑块微环境中可以促进招聘和保留单核吞噬细胞和随后的泡沫细胞形成。
Regulation of macrophage scavenger receptor (MSR) activity may be an important determinant of the extent of atherogenesis. The effect of macrophage-colony-stimulating factor (M-CSF) on this pathway was studied using a recently developed monoclonal antibody to murine MSR. M- CSF markedly and selectively increased MSR synthesis in murine macrophages: posttranslationally, the receptor appeared more stable and shifted to a predominantly surface distribution. Functionally, M-CSF enhanced modified lipoprotein uptake and increased divalent cation- independent adhesion in vitro. These results suggest a plausible mechanism whereby M-CSF production in the atheromatous plaque microenvironment could promote the recruitment and retention of mononuclear phagocytes and subsequent foam cell formation.