Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA
Effect of early antiretroviral therapy during primary HIV-1 infection on cell-associated HIV-1 DNA and plasma HIV-1 RNA
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DOI：
10.3851/imp1776
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发表时间：
2011-01-01
影响因子：
1.2
通讯作者：
Guenthard, Huldrych F.
中科院分区：
文献类型：
--
作者：
Gianella, Sara;von Wyl, Viktor;Guenthard, Huldrych F.
背景：在原发性 HIV-1 感染期间及早开始联合抗逆转录病毒治疗 (ART) 可能会阻止大型病毒库的建立，从而可能改善对 ART 停止后血浆病毒血症反弹的控制。方法：对 32 名开始 ART 的急性感染和近期感染患者的细胞相关 HIV-1 DNA 和血浆 HIV-1 RNA 水平进行纵向测量
Background: Early initiation of combination antiretroviral therapy (ART) during primary HIV-1 infection may prevent the establishment of large viral reservoirs, possibly resulting in improved control of plasma viraemia rebound after ART cessation.Methods: Levels of cell-associated HIV-1 DNA and plasma HIV-1 RNA were measured longitudinally in 32 acutely and recently infected patients, who started ART