B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study
B-vitamins in Relation to Depression in Older Adults Over 60 Years of Age: The Trinity Ulster Department of Agriculture (TUDA) Cohort Study
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DOI：
10.1016/j.jamda.2018.11.031
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发表时间：
2019-05-01
影响因子：
7.6
通讯作者：
McNulty, Helene
中科院分区：
文献类型：
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作者：
Moore, Katie;Hughes, Catherine F.;McNulty, Helene
目的：心理健康障碍是老年人疾病负担的主要贡献者。叶酸和代谢相关的B族维生素的缺乏状态可能与这些病症有关。本研究旨在调查叶酸、维生素B12、维生素B6和核黄素与老年抑郁和焦虑的关系，并考虑强化食品作为优化B族维生素状态和潜在降低这些心理健康疾病风险的一种手段的作用。设计：Trinity阿尔斯特农业部（TUDA）老龄化研究是一项横断面队列研究。从2008年至2012年从爱尔兰岛的两个管辖区招募了社区居住的成年人（n = 5186; >= 60岁）。测量：抑郁和焦虑分别使用流行病学研究抑郁中心（CES-D）和医院焦虑和抑郁（HAD）量表进行评估。测量以下B族维生素生物标志物：红细胞叶酸、血清总维生素B-12、血浆吡哆醛-5-磷酸（PLP;维生素B-6）和红细胞谷胱甘肽还原酶活化系数（EGRac;核黄素）。结果：生物标志物值处于最低20%状态的叶酸（优势比[OR] 1.79; 95% CI 1.23-2.61），维生素B-6（OR 1.45，95% CI 1.01-2.06）或核黄素（OR 1.56，95% CI 1.10-2.00），而不是维生素B-12，均与抑郁症风险增加相关（CES-D评分>= 16）。相应地，每天食用B维生素强化食品与抑郁症风险降低相关（OR 0.54，95%CI 0.41-0.70）。维生素B-6（OR 1.73，95%CI 1.07-2.81），但不是其他维生素的缺乏状态，与增加anxiety.Conclusions/Implications：更好的B族维生素状态可能有积极影响老年人的心理健康的作用。定期摄入强化食品可以提供一种优化B族维生素状态的方法，从而有助于减少抑郁症。如果得到随机试验的证实，这些结果可能对老年人的营养和心理健康政策以及生活质量产生影响。皇冠版权所有（C）2018由Elsevier Inc.代表AMDA -急性后和长期护理医学协会。
Objectives: Mental health disorders are major contributors to disease burden in older people. Deficient status of folate and the metabolically related B vitamins may be implicated in these conditions. This study aimed to investigate folate, vitamin B12, vitamin B6, and riboflavin in relation to depression and anxiety in aging and also considered the role of fortified foods as a means of optimizing B-vitamin status and potentially reducing the risk of these mental health disorders.Design: The Trinity Ulster Department of Agriculture (TUDA) aging study was a cross-sectional cohort study.Setting and Participants: Community-dwelling adults (n = 5186; >= 60 years) recruited from 2 jurisdictions within the island of Ireland from 2008 to 2012.Measures: Depression and anxiety were assessed using the Centre for Epidemiological Studies Depression (CES-D) and the Hospital Anxiety and Depression (HAD) scales, respectively. The following B-vitamin biomarkers were measured: red blood cell folate, serum total vitamin B-12, plasma pyridoxal-5-phosphate (PLP; vitamin B-6), and erythrocyte glutathione reductase activation coefficient (EGRac; riboflavin).Results: Biomarker values in the lowest 20% of status for folate (odds ratio [OR] 1.79; 95% CI 1.23-2.61), vitamin B-6 (OR 1.45, 95% CI 1.01-2.06), or riboflavin (OR 1.56, 95% CI 1.10-2.00), but not vitamin B-12, were each associated with an increased risk of depression (CES-D score >= 16). Correspondingly, B vitamine fortified foods if consumed daily were associated with a reduced risk of depression (OR 0.54, 95% CI 0.41-0.70). A deficient status of vitamin B-6 (OR 1.73, 95% CI 1.07-2.81), but not other vitamins, was associated with increased anxiety.Conclusions/Implications: Better B-vitamin status may have a role in impacting positively on mental health in older adults. Regular intake of fortified foods can provide a means of optimizing B-vitamin status and thus could contribute to reducing depression. If confirmed by a randomized trial, these results may have implications for nutrition and mental health policy, and thus quality of life, in older people. Crown Copyright (C) 2018 Published by Elsevier Inc. on behalf of AMDA - The Society for Post-Acute and Long-Term Care Medicine.