Preparation, characterization and antimicrobial study of a hydrogel (soft contact lens) material impregnated with silver nanoparticles
Preparation, characterization and antimicrobial study of a hydrogel (soft contact lens) material impregnated with silver nanoparticles
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DOI：
10.1016/j.clae.2013.09.008
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发表时间：
2014-06-01
影响因子：
3.2
通讯作者：
Mohajeri, Seyed Ahmad
中科院分区：
文献类型：
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作者：
Bazzaz, Bibi Sedigheh Fazly;Khameneh, Bahman;Mohajeri, Seyed Ahmad
目的：具有抗菌特性的角膜接触镜可降低透镜配戴者发生微生物相关不良事件的风险。本研究的目的是评估的抗菌效果的银纳米粒子（NP）浸渍在一个水凝胶material.Methods：水凝胶磁盘，用作代理软接触镜，制备与银纳米粒子添加抗菌效果的聚合物。产生六组盘，每组具有不同浓度的银NP。在6，24，48和72小时的水凝胶对铜绿假单胞菌（ATCC 15442）和金黄色葡萄球菌（ATCC 6538）的抗微生物效果进行了评价。结果：银NP浓度范围为20.71至98.06微克/盘。所有组在每个时间点均表现出对铜绿假单胞菌的优异抗菌作用。6 h后，所有盘均未表现出理想的抗菌活性。金黄色;而除了含有20.71 μ g银纳米颗粒的圆盘外，其他圆盘在24 h时均表现出抗菌活性，而只有含有57.13 μ g和98.06 μ g银纳米颗粒的圆盘在48 h和72 h时表现出抗菌活性。结论：由银纳米颗粒浸渍水凝胶材料制成的隐形眼镜的开发可能会带来足够的抗菌作用，以降低透镜佩戴者发生微生物相关不良事件的风险。(C)2013年英国接触透镜协会。由爱思唯尔有限公司出版。保留所有权利。
Purpose: Contact lenses that incorporate antimicrobial properties may reduce the risk for microbial-associated adverse events for lens wearers. The aim of this study was to assess the antimicrobial effects of silver nanoparticles (NP) when impregnated in a hydrogel material.Methods: Hydrogel disks, used as a proxy for soft contact lenses, were prepared with silver NPs to add an antimicrobial effect to the polymer. Six groups of disks were created, each with a different concentration of silver NPs. The antimicrobial effect of the hydrogels against Pseudomonas aeruginosa (ATCC15442) and Staphylococcus aureus (ATCC6538) was evaluated at 6, 24,48 and 72 h.Results: Silver NP concentrations ranged from 20.71 to 98.06 mu g/disk. All groups demonstrated excellent antibacterial effects against P. aeruginosa at each time point. After 6 h all disks didn't exhibit desirable antibacterial activity against S. aureus; whereas except those with 20.71 mu g silver NPs showed antibacterial activity at 24 h and only the disks with 57.13 and 98.06 mu g silver NPs showed antimicrobial activity at 48 and 72 h.Conclusions: The development of contact lenses made of a silver NP-impregnated hydrogel material may bring antimicrobial effects sufficient to decrease the risk of microbial-related adverse events for lens wearers. (C) 2013 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.