Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrysotherapy.
Ocular chrysiasis correlated with gold concentrations in the crystalline lens during chrysotherapy.
复制标题
眼金黄症与金黄疗法期间晶状体中的金浓度相关。
DOI：
10.1002/art.1780210616
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发表时间：
1978
影响因子：
--
通讯作者：
J. Major
中科院分区：
文献类型：
--
作者：
N. Gottlieb;J. Major
对11例接受延长金疗法（平均累积剂量大于7克，平均6年）的类风湿性关节炎（RA）患者的眼睛进行了生物显微镜检查。5例患者的角膜（角膜金黄色变性）和4例患者的透镜（透镜金黄色变性）中观察到微小的红紫色颗粒。其他11名未接受金治疗的RA患者中没有颗粒沉积物。由于偶然性白内障形成，从5位接受金治疗的患者手术取出7个晶状体，并使用中子活化分析法分析金含量。虽然这些患者的平均透镜金浓度高于非金治疗的对照组（0.0073微克/克对0.001微克/克），但绝对金水平明显低于先前分析的25种不同组织中发现的水平。这一发现与不存在临床金相关透镜疾病或视力损害相一致。
The eyes of 11 patients with rheumatoid arthritis (RA) who received extended chrysotherapy (mean cumulative dose greater than 7 grams during a mean 6-year period) were examined biomicroscopically. Minute reddish-purple particles were seen in the cornea (corneal chrysiasis) in 5 and in the lens (lens chrysiasis) in 4 patients. Particulate deposits were absent in 11 other RA patients who had not received gold treatment. Seven crystalline lenses from 5 gold-treated patients were removed surgically because of incidental cataract formation and analyzed for gold content using neutron activation analysis. Although the mean lens gold concentration was higher in these patients than in non-gold-treated controls without RA (0.0073 microgram/grams versus 0.001 microgram/grams), the absolute gold level was markedly lower than that found in 25 diverse tissue analyzed previously. This finding is compatible with the absence of clinical gold-related lens disease or visual impairment.