SYNTHESIS OF PYRROLIDINES AND PIPERIDINES VIA PALLADIUM-CATALYZED COUPLING OF VINYLIC HALIDES AND OLEFINIC SULFONAMIDES
SYNTHESIS OF PYRROLIDINES AND PIPERIDINES VIA PALLADIUM-CATALYZED COUPLING OF VINYLIC HALIDES AND OLEFINIC SULFONAMIDES
复制标题
DOI：
10.1021/jo00094a031
复制
发表时间：
1994-07-29
影响因子：
3.6
通讯作者：
HERR, RJ
中科院分区：
文献类型：
--
作者：
LAROCK, RC;YANG, H;HERR, RJ
钯催化的乙烯基卤化物和烯烃磺酰胺的偶联通过乙烯基钯加成烯烃，区域选择性重排成pi-烯丙基钯中间体，以及随后钯的分子内亲核位移，获得了2-（1-烯基）吡啶和-哌啶磺酰胺的高产率。
The palladium-catalyzed coupling of vinylic halides and olefinic sulfonamides affords good yields of 2-(1-alkenyl)pyrrolidine and -piperidine sulfonamides via vinylpalladium addition to the olefin, regioselective rearrangement to a pi-allylpalladium intermediate, and subsequent intramolecular nucleophilic displacement of palladium.