URINARY CORTISOL-LEVELS, CELLULAR IMMUNOCOMPETENCY, AND LONELINESS IN PSYCHIATRIC-INPATIENTS
URINARY CORTISOL-LEVELS, CELLULAR IMMUNOCOMPETENCY, AND LONELINESS IN PSYCHIATRIC-INPATIENTS
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DOI：
10.1097/00006842-198401000-00004
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发表时间：
1984-01-01
影响因子：
3.3
通讯作者：
GLASER, R
中科院分区：
文献类型：
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作者：
KIECOLTGLASER, JK;RICKER, D;GLASER, R
研究孤独感、应激性生活事件、尿皮质醇水平和免疫功能之间的关系。在入院后第二天从33名精神病住院患者中采集血液和尿液，此时患者完成UCLA [加州大学洛杉矶分校] LonnessScale、精神病流行病学研究访谈生活事件量表（PERI）和MMPI [明尼苏达多相人格调查表]。孤独得分高于中位数的患者尿皮质醇水平显著较高，自然杀伤细胞活性水平显著较低，T淋巴细胞对植物血凝素的反应较差。在MMPI测试中，高孤独感组的被试比低孤独感组的被试更痛苦。对免疫学指标或与PERI相关的MMPI没有一致的显著影响。
The associations among loneliness, stressful life events, urinary cortisol levels and immunocompetency were studied. Blood and urine were obtained from 33 psychiatric inpatients on the day after admission, at which time the patients completed the UCLA [University of California at Los Angeles] Loneliness Scale, the Psychiatric Epidemiology Research Interview Life Events Scale (PERI) and the MMPI [Minnesota Multiphasic Personality Inventory]. Patients who scored above the median on loneliness had significantly higher urinary cortisol levels, had significantly lower levels of natural killer cell activity and poorer T-lymphocyte response to phytohemagglutinin. The high loneliness subjects described themselves as more distressed than the low loneliness group on the MMPI. There were no consistent significant effects on either the immunologic measures or the MMPI associated with the PERI.